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| (R)-2-PHENYLPIPERIDINE Basic information |
| Product Name: | (R)-2-PHENYLPIPERIDINE | | Synonyms: | (R)-2-PHENYLPIPERIDINE;(R)-(+)-6-phenylpiperidine;Piperidine, 2-phenyl-, (2R)-;(R)-2-Phenylpiperidine 95%;(2R)-2-phenylpiperidine | | CAS: | 58613-54-0 | | MF: | C11H15N | | MW: | 161.24 | | EINECS: | | Product Categories: | | Mol File: | Mol File |
| (R)-2-PHENYLPIPERIDINE Chemical Properties |
| Boiling point | 257.3±19.0 °C(Predicted) | | density | 0.967±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | form | liquid | | pka | 9.74±0.10(Predicted) |
| (R)-2-PHENYLPIPERIDINE Usage And Synthesis |
| Uses | Chiral building block developed using Liverpool ChiroChem-patented technology. | | Synthesis | In a 10 mL one-necked round-bottomed flask equipped with a magnetic stir bar, rubber septum, and argon balloon was placed 0.033 g (0.19 mmol, 1 equiv.) of (R)-(+)-6-Phenylpiperidin-2-one and THF (1.2 mL). Lithium aluminum hydride (0.95 mL, 1.0 M solution in THF, 0.95 mmol) was added slowly via syringe and the reaction mixture was stirred at rt for 8 h. The solution was cooled to 0 °C, sat. Na2SO4 (0.17 mL) was added, stirred for 0.5 h at rt and the reaction mixture was filtered through Celite. The organic phases were concentrated and flash chromatography (7% MeOH/CH2Cl2) gave 0.025 g (82%) of (R)-2-phenylpiperidine as volatile oil. |
| (R)-2-PHENYLPIPERIDINE Preparation Products And Raw materials |
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