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| POLY-L-HISTIDINE HYDROCHLORIDE MW Basic information |
| POLY-L-HISTIDINE HYDROCHLORIDE MW Chemical Properties |
| POLY-L-HISTIDINE HYDROCHLORIDE MW Usage And Synthesis |
| Uses | Poly-L-histidine has been used:- as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
- as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
- in screening its anti-prion activity in cell based and in vivo anti-prion assay
| | General Description | Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation?deprotonation. | | Biochem/physiol Actions | Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)?poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment. |
| POLY-L-HISTIDINE HYDROCHLORIDE MW Preparation Products And Raw materials |
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