L-CYSTEINESULFINIC ACID MONOHYDRATE

CAS No.：207121-48-0

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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L-CYSTEINESULFINIC ACID MONOHYDRATE Basic information

Product Name:	L-CYSTEINESULFINIC ACID MONOHYDRATE
Synonyms:	(2R)-2-aMino-3-sulfinopropanoic acid;L-Cysteinesulfinic acid Monohydrate 99%;3-sulfino-l-alanine;(1R)-1-amino-2-mercaptoethanesulfinic acid hydrate;L-Cysteinesulfinic Acid (hydrate);Sulfino-L-alanine hydrate
CAS:	207121-48-0
MF:	HO2SCH2CH(NH2)CO2HH2O
MW:	171.17
EINECS:	623-116-9
Product Categories:	Amino Acids & Derivatives;Sulfur & Selenium Compounds
Mol File:	207121-48-0.mol

L-CYSTEINESULFINIC ACID MONOHYDRATE Chemical Properties

Melting point	163 °C (dec.)(lit.)
storage temp.	-20°C
optical activity	[α]25/D +24°, c = 1 in 1 M HCl
Stability:	Temperature Sensitive

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	2930901300

MSDS Information

L-CYSTEINESULFINIC ACID MONOHYDRATE Usage And Synthesis

Description	L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs). It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC₅₀s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC₅₀s = 100, 100, and 2,000 μM, respectively). It selectively binds to mGluR1α (K_i = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (K_is = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS). L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress.
Chemical Properties	Off-White Solid
Uses	An amino acid derivative with neuropathological interest; Putative excitatory amino acid neurotransmitter.
Uses	L-Cysteinesulfinic acid monohydrate has been used in the fluorescence measurement of cysteine oxidation.
Biochem/physiol Actions	Cysteinesulfinic acid (CSA), also called 3-sulfinoalanine is synthesized by the conversion of sulfur to sulfinic acid in cysteine by the enzyme cysteine dioxygenase (CDO). CSA is a putative excitatory amino acid (EAA) with neurotransmitter functionality. It also regulates cardiovascular functions.

L-CYSTEINESULFINIC ACID MONOHYDRATE Preparation Products And Raw materials

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