Other grades of this product :
| L-CYSTEINESULFINIC ACID MONOHYDRATE Basic information |
| L-CYSTEINESULFINIC ACID MONOHYDRATE Chemical Properties |
| Melting point | 163 °C (dec.)(lit.) | | storage temp. | -20°C | | optical activity | [α]25/D +24°, c = 1 in 1 M HCl | | Stability: | Temperature Sensitive |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 2930901300 |
| L-CYSTEINESULFINIC ACID MONOHYDRATE Usage And Synthesis |
| Description | L-Cysteinesulfinic acid is an excitatory amino acid and agonist of metabotropic glutamate receptors (mGluRs). It increases intracellular inositol phosphate levels in CHO cells expressing mGluR1, mGluR5, or mGluR8 (EC50s = 120, 30, and 110 μM, respectively) and inhibits forskolin-induced cAMP production in CHO cells expressing mGluR2 or mGluR6 and hamster kidney cells expressing mGluR4 (EC50s = 100, 100, and 2,000 μM, respectively). It selectively binds to mGluR1α (Ki = 3,510 nM) over adrenergic, dopamine, histamine, muscarinic, nicotinic, or serotonin receptors (Kis = >10,000 nM for all). L-Cysteinesulfinic acid (1 mM) decreases mean arterial blood pressure and heart rate in rats when microinjected into the nucleus tractus solitarius (NTS). L-Cysteinesulfinic acid can be formed via oxidation of L-cysteine by reactive oxygen species (ROS), and conversion of cysteine to L-cysteinesulfinic acid in cysteine-containing peptide probes has been used to measure oxidative stress. | | Chemical Properties | Off-White Solid | | Uses | An amino acid derivative with neuropathological interest; Putative excitatory amino acid neurotransmitter. | | Uses | L-Cysteinesulfinic acid monohydrate has been used in the fluorescence measurement of cysteine oxidation. | | Biochem/physiol Actions | Cysteinesulfinic acid (CSA), also called 3-sulfinoalanine is synthesized by the conversion of sulfur to sulfinic acid in cysteine by the enzyme cysteine dioxygenase (CDO). CSA is a putative excitatory amino acid (EAA) with neurotransmitter functionality. It also regulates cardiovascular functions. |
| L-CYSTEINESULFINIC ACID MONOHYDRATE Preparation Products And Raw materials |
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