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| 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Basic information |
| Product Name: | 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride | | Synonyms: | 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride;5,6,7,8-TETRAHYDRO-1,7-NAPHTHYRIDINE HCL;1,7-Naphthyridine, 5,6,7,8-tetrahydro- (hydrochloride) | | CAS: | 1338707-67-7 | | MF: | C8H11ClN2 | | MW: | 170.63934 | | EINECS: | | Product Categories: | | Mol File: | 1338707-67-7.mol |
| 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature |
| 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Usage And Synthesis |
| Uses | 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | 5,6,7,8-Tetrahydro-[1,7]napthyridine hydrochloride. A methanolic solution (25 mL) of 7-Benzyl-5,6,7,8-tetrahydro-[1,7]naphthyridine (J. Het. Chem. 2001, 38, 535) (1.5g, 6.69 mmol) was degassed with argon for 20 min followed by the addition of 4N HCl in dioxane (2 mL) and Pd/C (300 mg, 20 wt%) and stirred under 50 psi hydrogen pressure at room temperature for 24h. After completion of the reaction the mixture was filtered on a short pad of celite and washed with methanol (4 × 25 mL). The filtrate was evaporated to dryness in vacuo and crystallized from methanol. Yield: 65% (calculated as 2HCl salt), 900 mg, yellowish solid. |
| 5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Preparation Products And Raw materials |
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