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| N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Basic information |
| Product Name: | N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE | | Synonyms: | N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE;2-(N-methyl-p-toluidino)ethanol;N-Methyl-N-hydroxyethyl-P-toluidine;N-(2-Hydroxyethyl)-N-methyl-p-toluidine;2-[Methyl(4-methylphenyl)amino]ethanol;2-(N-Methyl-N-4-tolylamino)ethanol;FirstCure MHPT;N-Methyl-N-(2-hydroxyethyl)-p-toluidine | | CAS: | 2842-44-6 | | MF: | C10H15NO | | MW: | 165.23 | | EINECS: | 220-638-5 | | Product Categories: | | Mol File: | 2842-44-6.mol |
| N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Chemical Properties |
| Boiling point | 152-154 °C(Press: 10 Torr) | | density | 1.047±0.06 g/cm3(Predicted) | | vapor pressure | 0.062-0.115Pa at 20-25℃ | | storage temp. | Sealed in dry,Room Temperature | | form | Liquid:viscous | | pka | 14.69±0.10(Predicted) | | LogP | 2.2 at 25℃ and pH6 | | EPA Substance Registry System | Ethanol, 2-[methyl(4-methylphenyl)amino]- (2842-44-6) |
| N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Usage And Synthesis |
| Uses | N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE is an amine organic compound, which can be used as intermediate in organic synthesis. | | Synthesis |
Add reactant (0.2 mmol, 1.0 equiv), THF (2.0 mL) and CH2Br2 (0.6 mmol, 3.0 equiv) to a flame-dried 10 mL Schlenk tube in a glove box. Seal and take out of the glove box. Cool the reaction mixture to -78°C. Add nBuLi (0.56 mmol, 2.8 equiv) dropwise under N2 atmosphere within 3minutes. Stir the reaction at -78°C for 30 minutes and add ZnCl2 (0.1 mL, 0.5equiv, 1.0 M in Et2O). Allow the mixture to warm to room temperature and stir for 1 hour. Cool the mixture to 0°C. Add a premixture of H2O2 (30% in H2O, 0.5 mL) and NaOH (2.0 M, 1.0 mL). Stir the mixture at room temperature for another 1 hour and dilute with water (20 mL). Extract with DCM (30 mL x 2) and dry over Na2SO4. Filter and concentrate under vacuum. Purify the crude product by silica gel flash column chromatography to obtain product. 1H NMR (CDCl3, 500 MHz) δ 7.08 (d, J = 8.4 Hz, 2H), 6.78 (d, J = 8.4 Hz,2H), 3.80 (t, J = 5.6 Hz, 2H), 3.43 (t, J = 5.4 Hz, 2H), 2.93 (s, 3H), 2.28 (s, 3H), 2.01 (brs, 1H). 13C NMR (CDCl3, 125 MHz) δ 148.3, 129.8, 127.1, 114.0, 60.1, 56.2, 39.1, 20.4.
Fig The synthetic method of N-(2-hydroxyethyl)-N-methyl-4-toluidine
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| N-(2-HYDROXYETHYL)-N-METHYL-4-TOLUIDINE Preparation Products And Raw materials |
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