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| WILFORINE Basic information |
| Product Name: | WILFORINE | | Synonyms: | WILFORINE;(8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-8,11-epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione;8,11-Epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione,10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-,(8R,9R,10R,11S,1;(8α)-8-(Acetyloxy)-2-O-benzoyl-2-O-deacetyl-8-deoxoevonimine;(8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-10,13,22,23-Tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-8,11-epoxy-9,12-ethano-11,15-m;26-Deoxywilfordine;8,11-Epoxy-9,12-ethano-11,15-methano-5H,11H-[1,9]dioxacyclooctadecino[4,3-b]pyridine-5,17(18H)-dione, 10,13,22,23-tetrakis(acetyloxy)-12-[(acetyloxy)methyl]-14-(benzoyloxy)-7,8,9,10,12,13,14,15,19,20-decahydro-21-hydroxy-8,18,21-trimethyl-, (8R,9R,10R,11S,12S,13R,14R,15S,18S,21S,22S,23R)-;Evonimine, 8-(acetyloxy)-O2-benzoyl-O2-deacetyl-8-deoxo-, (8α)- | | CAS: | 11088-09-8 | | MF: | C43 H49 N O18 | | MW: | 867.85 | | EINECS: | | Product Categories: | reagent;standard substance | | Mol File: | 11088-09-8.mol |
| WILFORINE Chemical Properties |
| Melting point | 158-163℃ | | Boiling point | 871.5±65.0 °C(Predicted) | | density | 1.41 | | pka | 11.70±0.70(Predicted) |
| Toxicity | LD50 intraperitoneal in mouse: 418mg/kg |
| WILFORINE Usage And Synthesis |
| Description | Present in Tripterygiurn wilfordii Hook, this base forms colourless plates when
crystallized from MeOH-Me2CO. It has [α]25/sup>D + 30° (Me2CO).
| | Uses | Wilforine is a major bioactive sesquiterpene alkaloid extracted from Tripterygium wifordii Hook F. displaying anti-inflammatory activity. | | Definition | ChEBI: An organic heteropentacyclic compound and pyridine alkaloid with formula C43H49NO18 originally isolated from the roots of Tripterygium wilfordii. | | References | Beroza.,J. Arner. Chern. Soc., 74,3656 (1952)
Beroza., ibid, 75,44 (1953) |
| WILFORINE Preparation Products And Raw materials |
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