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| Product Name: | 4-Amino-3,5-dichloroacetophenone | | Synonyms: | 1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;1-(4-Amino-3,5-dichloro-phenyl)-2-ethanone;5-AMINO-3,5-DICHLORO ACETOPHENONE;4''-AMINO-3'',5''-DICHLOROACETOPHENONECLENBUTEROL;4-Amino-3,5-dichloroacetophenone,98%;4′-Amino-3′,5′-dichloroacetophenone,1-(4-Amino-3,5-dichlorophenyl)-ethanone, 3,5-Dichloro-4-aminoacetophenone;3,5-dichloro-p-aMino acetophenone;4-AMino-3,5-dichloroacetophenone, 98% 5GR | | CAS: | 37148-48-4 | | MF: | C8H7Cl2NO | | MW: | 204.05 | | EINECS: | 253-368-1 | | Product Categories: | Chemical Amines;Amines;Aromatic Acetophenones & Derivatives (substituted);(intermediate of leflunomide);Aromatics;37148-48-4 | | Mol File: | 37148-48-4.mol |
| 4-Amino-3,5-dichloroacetophenone Chemical Properties |
| Melting point | 162-166 °C(lit.) | | Boiling point | 351.5±42.0 °C(Predicted) | | density | 1.2748 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | -1.72±0.10(Predicted) | | color | Light Tan to Brown | | InChIKey | JLPKZJDZXIKSCP-UHFFFAOYSA-N | | CAS DataBase Reference | 37148-48-4(CAS DataBase Reference) |
| 4-Amino-3,5-dichloroacetophenone Usage And Synthesis |
| Description | 4-Amino-3,5-dichloroacetophenone is an intermediate in the synthesis of
the antitussive and antiasthmatic drug gramtin. | | Storage | 4-Amino-3,5-dichloroacetophenone should be stored in a cool, dry place
in a small, well filled, well-closed container, protected from light.
When a partially filled container is used, the air should be replaced by
nitrogen or another inert gas. 4-Amino-3,5-dichloroacetophenone
oxidizes on exposure to air, resulting in an increase in the peroxide
value. | | Chemical Properties | 4-Amino-3,5-dichloroacetophenone is a white to light yellow crystal powder. Insoluble in cold water, slightly soluble in hot water. | | Uses | 4-Amino-3,5-dichloroacetophenone is used to synthesize the drug Clenbuterol. Clenbuterol is a steroid-like chemical that was initially developed to treat asthma in horses, working by relaxing the airways in the animals'lungs. | | Preparation | 4-Amino-3,5-dichloroacetophenone was synthesized by chlorination of 4-aminoacetophenone. Add 4-aminoacetophenone and acetic acid (80%) into the reaction pot, stir and dissolve, quickly add chlorine-containing glacial acetic acid solution, the temperature of the addition is 5°C. After the addition is completed, immediately put into ice water to precipitate, filter, and wash with water to obtain the crude product. Recrystallize with ethanol to obtain the finished product of 4-Amino-3,5-dichloroacetophenone. | | Application | 4-Amino-3,5-dichloroacetophenone is a compound useful in organic synthesis. |
| 4-Amino-3,5-dichloroacetophenone Preparation Products And Raw materials |
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