Isonipecotic acid Nine Chongqing Chemdad Co. ，Ltd

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Isonipecotic acid

CAS No.：498-94-2

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Isonipecotic acid Basic information

Product Name:	Isonipecotic acid
Synonyms:	Isonipecotic acid, 4-Carboxypiperidine;4 - piperidine forMic acid;Isonipecotic aci;Isonipecotic acid, 99% 25GR;Piperidin-4-carboxylic acid;4-PIPERIDINECARBOXYLIC ACID FOR SYNTHESI;Piperidine-4-carboxylic acid or isonipecotic acid;AKOS BBS-00003783
CAS:	498-94-2
MF:	C6H11NO2
MW:	129.16
EINECS:	207-872-3
Product Categories:	Acids and Derivatives;Amines and Anilines;Nitrogen cyclic compounds;blocks;Carboxes;Heterocycles;Carboxylic Acids;Pyrans, Piperidines &Piperazines;Piperidine;Organic acids;Terfenadine Fexofenadine Ketanserin;Carboxylic Acids;Pyrans, Piperidines & Piperazines
Mol File:	498-94-2.mol

Isonipecotic acid Chemical Properties

Melting point	>300 °C(lit.)
Boiling point	239.22°C (rough estimate)
density	1.1426 (rough estimate)
refractive index	1.4587 (estimate)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Water
form	Powder
pka	pK1:3.73(+1);pK2:10.72(0) (25°C)
color	White to faint pink-beige
Water Solubility	soluble
Merck	14,5189
BRN	112553
CAS DataBase Reference	498-94-2(CAS DataBase Reference)
EPA Substance Registry System	4-Piperidinecarboxylic acid (498-94-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
RTECS	NS5150000
TSCA	T
HazardClass	IRRITANT
HS Code	29333999

MSDS Information

Provider	Language
4-Piperidinecarboxylic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

Isonipecotic acid Usage And Synthesis

Chemical Properties	white to faint pink-beige powder
Uses	A GABA-A receptor partial agonist
Synthesis Reference(s)	Synthesis, p. 623, 1984Tetrahedron Letters, 35, p. 8783, 1994 DOI: 10.1016/S0040-4039(00)78497-8
Purification Methods	It crystallises from H2O or EtOH as needles. The hydrochloride recrystallises from H2O or aqueous HCl with m 293odec (also 298odec, 300odec). [Wibaut Recl Trav Chim Pays-Bas 63 141 1944, IR: Zacharius et al. J Am Chem Soc 76 2908 1954, Beilstein 22/1 V 244.]

Isonipecotic acid Preparation Products And Raw materials

Preparation Products

4-Benzylpiperidine-->1-Boc-4-(aminomethyl)piperidine-->4-N-BOC-Aminopiperidine-->1-(PIPERIDIN-4-YLCARBONYL)PIPERIDINE-->4-Cyanopiperidine-->BENZYL 4-(BROMOMETHYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE-->1-ACETYL-4-BENZOYLPIPERIDINE-->PHENYL(PIPERIDIN-4-YL)METHANONE-->6-Fluoro-3-(4-piperidinyl)-1,2-benzisoxazole-->4-(Boc-Aminomethyl)piperidine-->1-tert-Butoxycarbonyl-4-piperidinecarboxaldehyde-->N-BOC-ISONIPECOTIC ACID-->1-Methylpiperidin-4-amine-->1-(4-ACETYLPIPERIDINO)ETHAN-1-ONE-->1-Boc-4-cyanopiperidine-->1-METHYLPIPERIDINE-4-CARBOXYLIC ACID HYDROCHLORIDE-->1-ACETYLISONIPECOTOYL CHLORIDE-->1-METHYL-PIPERIDINE-4-CARBOXYLIC ACID-->1-Acetyl-4-piperidinecarboxylic acid-->N-BOC-piperidine-4-carboxylic acid-->1-[(Benzyloxy)carbonyl]piperidine-4-carboxylic acid-->4-PIPERIDINECARBOXYLIC ACID T-BUTYL ESTER HCL

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