2-Chloro-4,6-dimethoxy-1,3,5-triazine Nine Chongqing Chemdad Co. ，Ltd

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2-Chloro-4,6-dimethoxy-1,3,5-triazine

CAS No.：3140-73-6

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2-Chloro-4,6-dimethoxy-1,3,5-triazine Basic information

Product Name:	2-Chloro-4,6-dimethoxy-1,3,5-triazine
Synonyms:	CDMT;AKOS 89995;2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE;2-CHLORO-4,6-DIMETHOXY-TRIAZINE;Chlorodimethoxytriazine;2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE, 9 7%;2-CHLORO-4,6-DIMETHOXY-1,3,5-TRIAZINE (CDMT);2-Chloro-4,6-dimethoxy-1
CAS:	3140-73-6
MF:	C5H6ClN3O2
MW:	175.57
EINECS:	221-541-0
Product Categories:	Miscellaneous;Aromatics;Biochemistry;Coupling Reactions (Peptide Synthesis);Heterocycles;Miscellaneous Reagents;Starting Raw Materials & Intermediates;Peptide Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Triazines;TriazinesBuilding Blocks;bc0001
Mol File:	3140-73-6.mol

2-Chloro-4,6-dimethoxy-1,3,5-triazine Chemical Properties

Melting point	71-74 °C (lit.)
Boiling point	99-100 °C (1 mmHg)
density	1.7917 (rough estimate)
vapor pressure	5.8Pa at 25℃
refractive index	1.5870 (estimate)
Fp	99-100°C/1mm
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform, Methanol
form	Crystalline Powder
pka	0.33±0.10(Predicted)
color	White to almost white
Water Solubility	insoluble
BRN	148988
InChIKey	GPIQOFWTZXXOOV-UHFFFAOYSA-N
LogP	2.105 at 25℃
CAS DataBase Reference	3140-73-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37-36
RIDADR	UN3077
WGK Germany	3
HS Code	29339900

MSDS Information

Provider	Language
2-Chloro-4,6-dimethoxy-1,3,5-triazine	English
ACROS	English
SigmaAldrich	English
ALFA	English

2-Chloro-4,6-dimethoxy-1,3,5-triazine Usage And Synthesis

Chemical Properties	white to almost white crystalline powder
Uses	2-Chloro-4,6-dimethoxy-1,3,5-triazine is used as a peptide coupling agent for the purification of peptides. It is used in the synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride through coupling with N-methylmorpholine in tetrahydrofuran. Further, it plays an important role in the production of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, through reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. In addition to this, it is involved in the preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts through reaction with various tertiary amines.
Uses	2-Chloro-4,6-dimethoxy-1,3,5-triazine may be used in the following studies: The specific labeling of streptavidin by the modular method for affinity labeling (MoAL). The preparation of bis(4,6-dimethoxy-1,3,5-triazin-2-yl) ether, via reaction with 2-hydroxy-4,6-dimethoxy-1,3,5-triazine. The preparation of 2-(4,6-dimethoxy-1,3,5-triazinyl)trialkylammonium salts, via reaction with various tertiary amines. The synthesis of 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride, via coupling with N-methylmorpholine in THF.
General Description	2-Chloro-4,6-dimethoxy-1,3,5-triazine is a stable, yet highly reactive, peptide coupling agent. It is reported as useful coupling reagent for the purification of peptides. Catalytic amide-forming reactions of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported. Procedure for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine has been reported.

2-Chloro-4,6-dimethoxy-1,3,5-triazine Preparation Products And Raw materials

Raw materials	Methanol-->PETROLEUM ETHER-->Sodium bicarbonate-->Cyanuric chloride
Preparation Products	Tulipalin A

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