4-Chloro-2-methylaniline Analytical Chemistry Chongqing Chemdad Co. ，Ltd

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4-Chloro-2-methylaniline

CAS No.：95-69-2

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4-Chloro-2-methylaniline Basic information

Product Name:	4-Chloro-2-methylaniline
Synonyms:	2-Amino-5-chlorotoluene 4-Chloro-o-toluidine 4-Chloro-2-methylaniline Fast Red TR Base 5-Chloro-2-aminotoluene 2-Methyl-4-chloroaniline;2-AMINO-5-CHLORTOLUENE;2-AMINO-5-CHLOROTOLUENE;2-methyl-4-chloroaniline;1-AMINO-4-CHLORO-6-METHYLBENZENE;4-Chloro-2-Methylaniline (4-Chloro-O-Toluidine)4,4'-Benzidine;4-Chloro-6-methylaniline;4-CHLORO-O-METHYLANILINE
CAS:	95-69-2
MF:	C7H8ClN
MW:	141.6
EINECS:	202-441-6
Product Categories:	Anilines, Aromatic Amines and Nitro Compounds
Mol File:	95-69-2.mol

4-Chloro-2-methylaniline Chemical Properties

Melting point	24-27 °C (lit.)
Boiling point	241 °C (lit.)
density	1.19 g/mL at 25 °C (lit.)
refractive index	n20/D1.583(lit.)
Fp	211 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Water Solubility	Practically insoluble in water
form	neat
pka	pK1:3.385(+1) (25°C)
color	White or colorless to Brown
BRN	878505
CAS DataBase Reference	95-69-2(CAS DataBase Reference)
NIST Chemistry Reference	Benzenamine, 4-chloro-2-methyl-(95-69-2)
IARC	2A (Vol. 77, 99) 2010
EPA Substance Registry System	4-Chloro-2-methylaniline (95-69-2)

Safety Information

Hazard Codes	T,N
Risk Statements	45-23/24/25-50/53-68
Safety Statements	53-45-60-61
RIDADR	UN 2239 6.1/PG 3
WGK Germany	3
RTECS	XU5000000
F	8-10
HazardClass	6.1(b)
PackingGroup	III
HS Code	29214300
Hazardous Substances Data	95-69-2(Hazardous Substances Data)

MSDS Information

Provider	Language
5-Chloro-2-aminotoluene	English
ACROS	English
SigmaAldrich	English

4-Chloro-2-methylaniline Usage And Synthesis

Chemical Properties	clear brown liquid
Chemical Properties	The chloromethylanilines are colorless or white crystalline solids or liquids, some have a mild fishy odor.
Uses	Intermediate.
Uses	4-Chloro-2-methylaniline may be used in the synthesis of the following: 2,8-dichloro-4,10-dimethyl-6H,12H-5,11-methanodibenzo[b,f]-diazocine via reaction with paraformaldehyde in toluene N-allylated derivative via palladium-catalyzed selective monoallylation with allyl alcohol N-(4-chloro-2-methylphenyl)benzamide via reaction with benzoyl chloride
General Description	Gray to white solid with a weak fishy odor. Sinks in water. Freezing point is 77°F.
Air & Water Reactions	May be sensitive to prolonged exposure to air and light. Insoluble in water.
Reactivity Profile	4-Chloro-2-methylaniline is incompatible with acids, acid chlorides, acid anhydrides, chloroformates and strong oxidizing agents. . A halogenated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Hazard	Toxic by ingestion and inhalation. Probable carcinogen.
Health Hazard	Inhalation, ingestion, or skin contact causes bluish tint in fingernails, lips, and ears. Headache, drowsiness, and nausea also occur. Contact with eyes causes irritation.
Fire Hazard	Special Hazards of Combustion Products: Toxic oxides of nitrogen and hydrochloric acid fumes may form.
Safety Profile	Confirmed carcinogen. Poison by ingestion and subcutaneous routes. Human mutation data reported. In the presence of copperpI) chloride catalyst decomposition occurs above 239'C. When heated to decomposition it emits toxic fumes of Cland NOx. See also other chloro toluidme entries.
Potential Exposure	Most of the isomers are used in dyestuff manufacture. The 3-chloro-para isomer is used to kill birds. It is marketed as pelleted bait for control of bird populations.
Carcinogenicity	p-Chloro-o-toluidine and its hydrochloride salt are reasonably anticipated to be human carcinogens based on limited evidence of carcinogenicity from studies in humans and evidence of carcinogenicity from studies in experimental animals.
Shipping	UN2239 Chlorotoluidines, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3429 Chlorotoluidines, liquid, Hazard Class: 6.1; Labels: 6.1- Poisonous materials
Incompatibilities	Incompatible with oxidizers, strong acids; chloroformates, and acid anhydrides, isocyanates, aldehydes forming fire and explosive hazards.

4-Chloro-2-methylaniline Preparation Products And Raw materials

Raw materials	Glycine-->Benzoyl chloride-->o-Toluidine-->2-NITROSOTOLUENE-->2-Methylphenyl azide-->4-CHLORO-2-METHYLPHENYLBORONIC ACID-->1-Bromo-4-chloro-2-methylbenzene-->2-METHYLACETANILIDE-->5-Chloro-2-nitrotoluene-->4-Chloro-2-methylaniline
Preparation Products	4-CHLORO-2-METHYLBENZOIC ACID-->CHLOROMETHIURON-->4-CHLORO-2-METHYLPHENYL ISOTHIOCYANATE-->2-Chloro-6-methylaniline-->CHLORDIMEFORM-->4-Chloro-N-methylaniline-->5-CHLORO-7-METHYLISATIN-->Disperse Red 220-->4'-Chloro-3-hydroxy-2'-methyl-2-naphthanilide-->ANTHRA RED B-->4-Chloro-2-methylaniline

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