3-Methylpiperidine
3-Methylpiperidine
  • CAS No.:626-56-2
Other grades of this product :
3-Methylpiperidine Basic information
Product Name:3-Methylpiperidine
Synonyms:β-Pipecoline, 3-Pipecoline;3-Methylpiperidine ,99%;(R,S)-3-Methyl-piperidine;3-methyl-piperidin;3-methylpiperidine(corrosiveliquid,flammable,n.o.s.);3-pipercoline(beta-);beta-Methylpiperidine;3-Methylpiperidine, 99% 5GR
CAS:626-56-2
MF:C6H13N
MW:99.17
EINECS:210-953-6
Product Categories:Piperidine;Piperidines, Piperidones, Piperazines
Mol File:626-56-2.mol
3-Methylpiperidine Chemical Properties
Melting point -24 °C
Boiling point 125-126 °C/763 mmHg (lit.)
density 0.845 g/mL at 25 °C (lit.)
refractive index n20/D 1.447(lit.)
Fp 63 °F
storage temp. Flammables area
pkapK1:11.07(+1) (25°C)
form clear liquid
color Colorless to Light yellow to Light orange
Water Solubility miscible
BRN 79807
CAS DataBase Reference626-56-2(CAS DataBase Reference)
NIST Chemistry ReferencePiperidine, 3-methyl-(626-56-2)
EPA Substance Registry SystemPiperidine, 3-methyl- (626-56-2)
Safety Information
Hazard Codes F,Xi
Risk Statements 11-36/37/38
Safety Statements 16-23-33-26-7/9
RIDADR UN 1993 3/PG 2
WGK Germany 3
TSCA Yes
HazardClass 3
PackingGroup II
HS Code 29333990
MSDS Information
ProviderLanguage
3-Methylpiperidine English
SigmaAldrich English
ACROS English
ALFA English
3-Methylpiperidine Usage And Synthesis
Chemical Propertiesclear colorless to yellow liquid
Uses3-Methylpiperidine, is used as a reactant for synthesis of Phenylpropenamide derivatives for anti-hepatitis B virus activity, CB2 receptor agonists for treatment of chronic pain, aurora kinase inhibitors, spiroimidazolidinone NPC1L1 inhibitors, 1,3,5-Oxadiazinones, selective serotonin 5-HT6 receptor antagonists. It is also used as a pharmaceutical intermediate and as a intermediate in organic synthesis.
General DescriptionA colorless liquid with a characteristic odor. Less dense than water. Flash point less than 141°F. Contact may cause severe irritation to skin, eyes, and mucous membranes. Toxic by ingestion, inhalation and skin absorption.
Air & Water ReactionsHighly flammable. Water soluble.
Reactivity Profile3-METHYLPIPERIDINE neutralizes acids to form salts plus water in exothermic reactions. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Generates flammable gaseous hydrogen in combination with strong reducing agents, such as hydrides.
Health HazardMay cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire HazardFlammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Purification MethodsPurify it via the hydrochloride (m 172o). The hydrobromide has m 162-163o(from iso-PrOH). [Chapman et al. J Chem Soc 1925 1959, Beilstein 20 III/IV 1499, 20/4 V 100.]
3-Methylpiperidine Preparation Products And Raw materials

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