L-tert-Leucine
L-tert-Leucine
  • CAS No.:20859-02-3
Other grades of this product :
L-tert-Leucine Basic information
Description References
Product Name:L-tert-Leucine
Synonyms:(S)-(+)-LEUCINE;RARECHEM AB PP 3754;L-A-AMINO-G-METHYL VALERIC ACID;L-A-AMINOISOCAPROIC ACID;L-2-AMINO-4-METHYLVALERIC ACID;LEUCINE, L-;LEU;LEUCINE
CAS:20859-02-3
MF:C6H13NO2
MW:131.17
EINECS:424-750-7
Product Categories:Telaprevir intermediate;.;API intermediates;PROTECTED AMINO ACID & PEPTIDES;Amino Acids;Leucine [Leu, L];Amino acids, non natural;Chiral Compounds;API;Peptide;amino acid
Mol File:20859-02-3.mol
L-tert-Leucine Chemical Properties
Melting point ≥300 °C (lit.)
alpha 6.3 º (c=4, 6 N HCl 200 ºC)
Boiling point 217.7±23.0 °C(Predicted)
density 1.1720 (estimate)
refractive index -9 ° (C=3, H2O)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility 1 M HCl: 50 mg/mL
pka2.39±0.12(Predicted)
form powder
color White to almost white
optical activity[α]20/D 9.5°, c = 3 in H2O
Water Solubility 125.5 g/L (20 ºC)
BRN 1721824
InChIKeyNPDBDJFLKKQMCM-SCSAIBSYSA-N
CAS DataBase Reference20859-02-3(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 22-24/25
WGK Germany 3
RTECS OH2850000
Hazard Note Irritant
HS Code 29224999
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
L-tert-Leucine Usage And Synthesis
DescriptionL-tert-Leucine is an essential amino acid making up one third of our muscle protein. L-tert-leucine is important in developing chiral pharmaceutically active chemicals. It can be used as a food additive. It is used in the formation of sterols. It can also be used as the catalyst in the production of cobalt oxazoline palladacycles complex. It can also be used for the production of Chiral tridentate Schiff base ligands.
ReferencesKorkmaz, Neslihan, D. Astley, and S. T. Astley. "Tridentate ligands derived from L-tert-Leucine for the Cu(II) mediated asymmetric Henry reaction." Turkish Journal of Chemistry 35.3(2011):1-17. https://www.alfa.com/en/catalog/L13707/ http://igem.org/abstract_pdf_file.cgi?id=1719
Chemical PropertiesWhite to almost white powder
UsesL-tert-Leucine is an essential amino acid and makes up one third of our muscle protein. It can be used as a food additive. It is used in the formation of sterols. It is used in the production of cobalt oxazoline palladacycles complex, which acts as a catalyst in the rearrangement of prochiral N-aryl trifluoroacetimidates to allylic amides yielded in significantly higher enantioselectivities with the (S)-(pR)-diasteroisomer.
Synthesis Reference(s)Organic Syntheses, Coll. Vol. 3, p. 523, 1955Tetrahedron Letters, 19, p. 4625, 1978 DOI: 10.1016/S0040-4039(01)85688-4

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