N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine
N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine
  • CAS No.:1421372-94-2
Other grades of this product :
N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Basic information
Product Name:N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine
Synonyms:N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine;2-PyriMidinaMine, N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methyl-1H-indol-3-yl)-;N-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine;(4-Fluoro-2-methoxy-5-nitro-phenyl)-[4-(1-methyl-1h-indol-3-yl)-pyrimidin-2-yl]-amine;N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)pyrimidin-2-amine;AZD9291 1;OSIMERTINIB INTERMEDIATE 1;N-(4-fluoro-2-methoxy-5-nitrophenyl)- 4-(1-methylindol-3-yl)pyrimidin-2-amine(AZD9291 Intermediate 2)
CAS:1421372-94-2
MF:C20H16FN5O3
MW:393.37
EINECS:806-156-3
Product Categories:AZD9291
Mol File:1421372-94-2.mol
N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Chemical Properties
Melting point >250°C (dec.)
Boiling point 639.3±65.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility DMSO (Slightly, Heated)
pka2.02±0.10(Predicted)
form Solid
color Light Yellow to Yellow
Safety Information
MSDS Information
N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Usage And Synthesis
UsesN-(4-Fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-2-pyrimidinamine functions as a reagent in the synthesis of dihydropyrroloquinoline derivatives with anticancer activity as EGFR modulator to inhibit L858R/T790M.
N-(4-fluoro-2-Methoxy-5-nitrophenyl)-4-(1-Methylindol-3-yl)pyriMidin-2-aMine Preparation Products And Raw materials
Raw materials3-(2-chloropyriMidin-4-yl)-1-Methylindole-->4-fluoro-2-Methoxy-5-nitroaniline-->1-Methylindole-->2,4-DIFLUORO-5-NITROANILINE-->3-(2-chloropyriMidin-4-yl)-1H-indole-->4-FLUORO-2-METHOXYANILINE-->Indole-->2,4-Difluoroaniline
Preparation ProductsAZ 7550

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