| 7-Hydroxygranisetron Basic information |
| Product Name: | 7-Hydroxygranisetron |
| Synonyms: | 1H-INDAZOL-3-CARBONIC ACID;1H-INDAZOLE-3-CARBOXYLIC ACID;1H-INDAZOLE-3-CARBONIC ACID;AKOS BB-9978;3-INDAZOLECARBOXYLIC ACID;3-CARBOXYINDAZOLE;ndazole-3-carboxylic acid;INDAZOLE-3-CARBOXYLIC ACID |
| CAS: | 4498-67-3 |
| MF: | C8H6N2O2 |
| MW: | 162.15 |
| EINECS: | 224-794-5 |
| Product Categories: | Indoles and derivatives;pharmacetical;Acids and Derivatives;Heterocycles;Carboxylic Acids;Organic acids;PHARMACEUTICAL INTERMEDIATES;(intermediate of granisetron);Indazoles;Indole Derivatives;Carboxylic Acids;Fused Ring Systems;Building Blocks;Heterocyclic Building Blocks |
| Mol File: | 4498-67-3.mol |
| 7-Hydroxygranisetron Chemical Properties |
| Melting point | 266-270 °C (dec.) |
| Boiling point | 443.7±18.0 °C(Predicted) |
| density | 1.506±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| pka | 3.03±0.10(Predicted) |
| form | powder |
| color | beige |
| BRN | 6354 |
| InChIKey | BHXVYTQDWMQVBI-UHFFFAOYSA-N |
| CAS DataBase Reference | 4498-67-3(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36-36/37/38 |
| Safety Statements | 26-36/37/39-22 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29339900 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| 7-Hydroxygranisetron Usage And Synthesis |
| Chemical Properties | yellow crystal |
| Uses | Indazole-3-carboxylic acid is indole derivatives useful in treatment of pain and inflammation |
| Uses | Indazole-3-carboxylic acid may be used in the synthesis of the following:
|
| Synthesis Reference(s) | Journal of Heterocyclic Chemistry, 26, p. 531, 1989 DOI: 10.1002/jhet.5570260251 |
| 7-Hydroxygranisetron Preparation Products And Raw materials |
| Raw materials | Sodium hydroxide-->Hydrochloric acid-->Sulfuric acid-->Acetic acid-->Sodium nitrite-->Stannous chloride dihydrate-->STANNOUS CHLORIDE-->Isatin |
| Preparation Products | Lonidamine-->3-Methylindole-->1H-INDAZOLE-3-(N-METHOXY-METHYL)CARBAMIDE-->5-BROMO-1H-INDAZOLE-3-CARBALDEHYDE-->1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER |
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