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| (S)-3-Hydroxy-gamma-butyrolactone Basic information |
| (S)-3-Hydroxy-gamma-butyrolactone Chemical Properties |
| Boiling point | 98-100 °C0.3 mm Hg(lit.) | | density | 1.241 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.464(lit.) | | Fp | >230 °F | | storage temp. | Inert atmosphere,2-8°C | | pka | 12.87±0.20(Predicted) | | optical activity | [α]21/D 81°, c = 2 in ethanol | | Water Solubility | Miscible with water, alcohol and other organic solvent. Immiscible with light petroleum. | | BRN | 1280864 | | CAS DataBase Reference | 7331-52-4(CAS DataBase Reference) |
| (S)-3-Hydroxy-gamma-butyrolactone Usage And Synthesis |
| Description | (S)-3-Hydroxy-gamma-butyrolactone is an important intermediate in organic synthesis and an important chiral pool. It is mainly used in the synthesis of some natural products and some bioactive chiral drugs or antibiotic chiral drugs. For example, it is a key intermediate in synthesis of nerve regulator (R)-GABOB and brain metabolic accelerant S-oxiracetam (S-ORC). It can be deoxidized to (S)-(+)-3-Hydroxytetrahydrofuran which is an important intermediate of anti-AIDS drugs. It is also used in the synthesis of S(-)-3-hydroxy-4-bromobutyric acid which is a potential stabilizer. | | Chemical Properties | Colorless to light yellow liquid. | | Uses | (S)-3-Hydroxy-γ-butyrolactone can be used as an anticancer drug resistance inhibitor. | | Precautions | For best results, Store in cool, dry place in tightly closed containers, under inert gas and protected from moisture as this substance is moisture sensitive. (S)-3-Hydroxy-gamma-butyrolactone is incompatible with oxidizing agents. This chemical causes skin irritation and serious eye irritation. |
| (S)-3-Hydroxy-gamma-butyrolactone Preparation Products And Raw materials |
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