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| 7-Nitroindazole Basic information |
| 7-Nitroindazole Chemical Properties |
| Melting point | 185-186°C | | Boiling point | 290.19°C (rough estimate) | | density | 1.4141 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | -20°C | | pka | 10.03±0.40(Predicted) | | form | powder to crystal | | color | Light yellow to Brown | | Water Solubility | slightly soluble | | BRN | 6809 | | CAS DataBase Reference | 2942-42-9(CAS DataBase Reference) | | NIST Chemistry Reference | 7-Nitroindazole(2942-42-9) |
| Hazard Codes | T | | Risk Statements | 60-40 | | Safety Statements | 53-22-36/37/39-45 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | RTECS | NK7962200 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 29339900 |
| 7-Nitroindazole Usage And Synthesis |
| Description | 7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro. However, it shows good anti-nociceptive effects in vivo without affecting blood pressure via inhibition of eNOS. The IC50 values for inhibition of rat nNOS, bovine eNOS, and rat iNOS are 0.71, 0.78, and 5.8 μM, respectively. | | Chemical Properties | yellow powder or Yellow orange solid soluble in DMSO. | | Uses | 7-nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS), an enzyme that converts arginine to citrulline and nitric oxide (NO) in neuronal tissue. NO is a key player in the hippocampal long-term potentiation (LTP) and in general cell signaling. | | Definition | 7-Nitroindazole is a heterocyclic small molecule containing an indazole ring that has been nitrated at the 7 position. It is a potent, selective brain inhibitor of mouse cerebellar Nitric Oxide Synthase, a hemoprotein enzyme that, in neuronal tissue, converts arginine to citrulline and nitric oxide (NO). | | Biological Activity | Sodium salt of the non-selective NOS inhibitor 7-nitroindazole (7-Nitroindazole). |
| 7-Nitroindazole Preparation Products And Raw materials |
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