Glycinamide hydrochloride

Glycinamide hydrochloride structure
  • CAS No.:1668-10-6
Other grades of this product :
Glycinamide hydrochloride Basic information
Product Name:Glycinamide hydrochloride
Synonyms:Acetamide, 2-amino-, monohydrochloride;GLYCINAMIDEHYDROCHLORIDE,BIOLOGICALBUFFER;GLYCINAMIDE HCI;Aminoacetamide hydrochloride;Glycinamide hydrochloride,98%;GlycinaMide hydrochloride, 98% 25GR;Glycinamide hydrochl;Acetamide, 2-amino-,hydrochloride (1:1)
CAS:1668-10-6
MF:C2H7ClN2O
MW:110.54
EINECS:216-789-1
Product Categories:Glycine [Gly, G];Amino Acids and Derivatives;Amino hydrochloride;Amides;Carbonyl Compounds;Organic Building Blocks;Amino Acid Derivatives;(intermediate of oxiracetam);Amino Acids;A - HOrganic Building Blocks;Amino Acids;Modified Amino Acids;A - H;Modified Amino Acids;Biochemicals and Reagents;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Pyridines
Mol File:1668-10-6.mol
Glycinamide hydrochloride Chemical Properties
Melting point 204 °C (dec.)(lit.)
storage temp. Inert atmosphere,Room Temperature
solubility H2O: 0.1 g/mL, clear
form Crystalline Powder
color White to beige
pka8.20(at 20℃)
Water Solubility Soluble in water (1100g/L).
Sensitive Hygroscopic
λmaxλ: 260 nm Amax: 0.1
BRN 3554199
Stability:Hygroscopic
InChIKeyWKNMKGVLOWGGOU-UHFFFAOYSA-N
CAS DataBase Reference1668-10-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 22-24/25-37/39-26
WGK Germany 3
F 3-10
HazardClass IRRITANT
HS Code 29241900
MSDS Information
ProviderLanguage
Glycinamide hydrochloride English
ACROS English
SigmaAldrich English
ALFA English
Glycinamide hydrochloride Usage And Synthesis
Chemical PropertiesCrystalline
UsesGlycinamide hydrochloride is a buffer that is useful in the physiological pH range. And it is also used as a pharmaceutical intermediate, in the organic synthesis.
UsesGlycinamide hydrochloride may be used in the synthesis of [M(glycinamidato-N,N′)(ptpy)2] where ptpy = 2-(p-tolyl)pyridinato) and M= Rh or Ir. It may be used in the synthesis of the following glycinamide-based imidazolidinones:
  • (±)-2-(2-phenylpropyl)imidazolidin-4-one
  • (±)-2-(2,4,4-trimethylpentyl)imidazolidin-4-one
  • (±)-2-[(R)-2,6-dimethyl-5-heptenyl]imidazolidin-4-one
  • (5R,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one
  • (5S,6S,9R)-6-isopropyl-9-methyl-1,4-diazaspiro[4.5]decan-2-one
  • (±)-2-methyl-2-pentylimidazolidin-4-one
  • (±)-2-ethyl-2-(2-methylbutyl)imidazolidin-4-one
  • (±)-2-(undecan-2-yl)imidazolidin-4-one
  • (±)-2-pentylimidazolidin-4-one
  • 2-(2,4-dimethylcyclohex-3-en-1-yl)imidazolidin-4-one
Purification MethodsCrystallise the salt from EtOH, EtOH/H2O or MeOH. [Karmas & Spoerri J Am Chem Soc 74 1580 1952, Beilstein 4 IV 2358.]
Glycinamide hydrochloride Preparation Products And Raw materials
Raw materialsMethyl chloroacetate-->Glycinamide
Preparation Productsthiazol-3-one-->Z-GLY-NH2

Important Notice

  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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