| Hydroxy-PEG-5-t-butyl ester Basic information |
| Product Name: | Hydroxy-PEG-5-t-butyl ester |
| Synonyms: | HO-PEG4-CH2CH2COOTBU;Hydroxy-PEG-5-t-butyl ester;PEG5-t-butly ester;Hydroxy-PEG4-t-butly ester;OH-PEG4-CH2CH2COOtBu;OH-PEG4-TBA;HO-PEG4-COOtBu;t-Butyl 3-Hydroxy(PEG4)propoinate |
| CAS: | 518044-32-1 |
| MF: | C15H30O7 |
| MW: | 322.39 |
| EINECS: | |
| Product Categories: | peg |
| Mol File: | 518044-32-1.mol |
| Hydroxy-PEG-5-t-butyl ester Chemical Properties |
| Boiling point | 406.8±35.0 °C(Predicted) |
| density | 1.04746 g/mL |
| refractive index | n/D 1.4492 |
| storage temp. | 2-8°C |
| solubility | Soluble in Water, DCM |
| pka | 14.36±0.10(Predicted) |
| form | liquid |
| color | Colorless to Light yellow to Light orange |
| Safety Information |
| HS Code | 2918999090 |
| MSDS Information |
| Hydroxy-PEG-5-t-butyl ester Usage And Synthesis |
| Description | Hydroxy-PEG4-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. |
| Uses | This heterobifunctional, PEGylated crosslinker features a hydroxyl group at one end and t-butyl-protected carboxylic acid at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Hydroxy-PEG4-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| Hydroxy-PEG-5-t-butyl ester Preparation Products And Raw materials |
| Preparation Products | Bromo-PEG4-t-butyl ester-->H2N-PEG4-tBu |
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