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| D-(-)-MANDELIC ACID BENZYL ESTER Basic information |
| D-(-)-MANDELIC ACID BENZYL ESTER Chemical Properties |
| Melting point | 104-107 °C(lit.) | | Boiling point | 387℃ | | density | 1.204 | | refractive index | -34 ° (C=1, CH3CN) | | Fp | 163℃ | | storage temp. | Sealed in dry,Room Temperature | | pka | 12.15±0.20(Predicted) | | form | powder to crystal | | color | White to Almost white | | optical activity | [α]25/D 55°, c = 1 in chloroform | | CAS DataBase Reference | 97415-09-3 |
| Safety Statements | 24/25 | | WGK Germany | 3 | | HS Code | 29181990 |
| D-(-)-MANDELIC ACID BENZYL ESTER Usage And Synthesis |
| Description | (R)-benzyl Mandelate is a synthetic intermediate useful for pharmaceutical synthesis. | | Uses | Benzyl (R)-(-)-mandelate can be employed as reactant to synthesize: - (S)-α-Hydroxy-N-(2-phenylethyl)benzenepropanamide (α-hydroxyamides) by enzyme catalyzed amidation reaction.
- Optically pure (R)- monomethyl esters of 3-[(tert-butyldimethylsilyl)oxy]pentanedioic acid, which is employed in the preparation of HMG-CoA reductase inhibitors.
- O-Ibuprofenylmandelic acid via acylation reaction with optically active ibuprofen and subsequent hydrogenation.
- Benzyl (R)-2-fluoro-2-phenylacetate via deoxyfluorination of alcohols using AlkylFluor.
It can also be used to prepare HMG-CoA reductase inhibitors. | | Uses | D-(-)-Mandelic Acid Benzyl Ester is a useful reagent for the preparation of a pharmaceutical composition for treating atopic dermatitis. |
| D-(-)-MANDELIC ACID BENZYL ESTER Preparation Products And Raw materials |
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