| Paricalcitol Basic information |
| Product Name: | Paricalcitol |
| Synonyms: | CS-1390;PARICALCITOL (10 MG)F0E3030.997MG/MG(AI);PARICALCITOL;19-nor-1alpha,25-dihydroxyvitamin D2;(1R,3R)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-Hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]cyclohexane-1,3-diol;Zemplar;1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,3R,5Z)-;Paricalcitol, >=98% |
| CAS: | 131918-61-1 |
| MF: | C27H44O3 |
| MW: | 416.65 |
| EINECS: | 658-064-6 |
| Product Categories: | Vitamin D3 analogs;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 131918-61-1.mol |
| Paricalcitol Chemical Properties |
| Boiling point | 564.8±50.0 °C(Predicted) |
| density | 1.121±0.06 g/cm3(Predicted) |
| Fp | 14℃ |
| form | neat |
| pka | 14.34±0.40(Predicted) |
| InChIKey | BPKAHTKRCLCHEA-UBFJEZKGSA-N |
| CAS DataBase Reference | 131918-61-1(CAS DataBase Reference) |
| Safety Information |
| RIDADR | UN1170 - class 3 - PG 2 - Ethanol, solution |
| HS Code | 2936299055 |
| Hazardous Substances Data | 131918-61-1(Hazardous Substances Data) |
| MSDS Information |
| Paricalcitol Usage And Synthesis |
| Description | Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well. |
| Description | Paricalcitol was launched as Zemplar in the US for the prevention and treatment of secondary hyperthyroidism associated with chronic renal failure. Paricalcitol is a synthetic vitamin D2, namely a novel 1-alpha-hydroxy-19-noranalogue in which the ring A exocyclic methylene group, typical of all vitamin D systems, has been replaced by two hydrogen atoms. Paricalcitol is the first vitamin D analogue marketed for this indication. In patients with chronic renal failure, Paricalcitol appreciably reduced levels of parathyroid hormone (PTH) without a significant difference in the incidence rate for hypercalcemia or hyperphosphatemia when compared with placebo. |
| Chemical Properties | White Solid |
| Originator | Abbott (US) |
| Uses | Synthetic analog of vitamin D. Antihyperparathyroid. |
| Uses | Antihyperparathyriod |
| Uses | 1,25-Dihydroxy vitamin D2 is a potent agonist of the vitamin D receptor. Paricalcitol is a synthetic 1,25-dihydroxy vitamin D2 analog. As vitamin D deficiency, associated with chronic kidney disease, leads to an increase in parathyroid hormone (secondary hyperparathyroidism), paricalcitol is used in renal patients to block parathyroid hormone overproduction. Vitamin D deficiency is also a risk factor in cancer, cardiovascular disease, hypertension, and diabetes, and paricalcitol may have applications in those contexts as well. |
| Brand name | Zemplar (Abbott). |
| Clinical Use | Vitamin D analogue: Treatment and prevention of secondary hyperparathyroidism associated with chronic renal failure |
| Drug interactions | Potentially hazardous interactions with other drugs None known |
| Metabolism | Extensively metabolised via hepatic and non-hepatic pathways to form two relatively inactive metabolites. After oral administration of 3 H-paricalcitol, only about 2% of the dose was eliminated unchanged in the faeces, and no parent drug found in the urine. Approximately 70% of the radioactivity was eliminated in the faeces and 18% was recovered in the urine. Most of the systemic exposure was from the parent drug. |
| Paricalcitol Preparation Products And Raw materials |
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