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| Disuccinimidyl glutarate Basic information |
| Disuccinimidyl glutarate Chemical Properties |
| Melting point | 168-172 °C | | Boiling point | 485.1±55.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO (Sparingly, Sonicated), Methanol (Slightly, Sonicated) | | form | Solid | | color | White to Off-White | | Water Solubility | Soluble in dimethylsulfoxide and dimethylformamide. Partially soluble in water. | | Sensitive | Moisture Sensitive | | BRN | 8575145 | | Stability: | Hygroscopic, Moisture Sensitive, Unstable in Aqueous Solution | | InChIKey | LNQHREYHFRFJAU-UHFFFAOYSA-N | | CAS DataBase Reference | 79642-50-5 |
| Disuccinimidyl glutarate Usage And Synthesis |
| Description | Disuccinimidyl glutarate (DSG) is a homobifunctional crosslinking agent that contains amine-reactive N-hydroxysuccinimide (NHS) ester groups at each end. DSG is membrane-permeable and non-cleavable. DSG can be combined with formaldehyde fixation to improve the detection of specific protein-DNA complexes. | | Characteristics | Features of disuccinimidyl glutarate:Reactive groups: NHS ester (both ends)Reactive towards: amino groups (primary amines)Non-cleavableWater-insoluble (dissolve first in DMF or DMSO)Membrane-permeable, allowing for intracellular crosslinkingCan increase crosslinking efficiency compared to DSS in some applications | | Uses | Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor. |
| Disuccinimidyl glutarate Preparation Products And Raw materials |
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