D-Pyroglutamic acid Eight Chongqing Chemdad Co. ，Ltd

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D-Pyroglutamic acid

CAS No.：4042-36-8

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D-Pyroglutamic acid Basic information

Product Name:	D-Pyroglutamic acid
Synonyms:	(R)-5-PYRROLIDONE-2-CARBOXYLIC ACID;(R)-(+)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID;(R)-5-OXO-2-PYRROLIDINECARBOXYLIC ACID;(R)-5-OXOPYRROLIDINE-2-CARBOXYLIC ACID;(R)-(+)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;(R)-2-PYRROLIDINONE-5-CARBOXYLIC ACID;(R)-(+)-2-PYRROLIDONE-5-CARBOXYLIC ACID;(R)-2-PYRROLIDONE-5-CARBOXYLIC ACID
CAS:	4042-36-8
MF:	C5H7NO3
MW:	129.11
EINECS:	223-735-0
Product Categories:	Amino Acids & Derivatives;Chiral Reagents;Pyroglutamic acid [Pyr, pGu];Amino Acids 13C, 2H, 15N;Amino Acids;amino acid;Amino Acids and Derivatives;Heterocycles;chiral;Biochemistry;Biological-modified Amino Acids;for Resolution of Bases;Optical Resolution;Synthetic Organic Chemistry;pharmacetical;bc0001
Mol File:	4042-36-8.mol

D-Pyroglutamic acid Chemical Properties

Melting point	155-162 °C
alpha	27.5 º (c=10,1N NaOH)
Boiling point	239.15°C (rough estimate)
density	1.3816 (rough estimate)
refractive index	10 ° (C=5, H2O)
storage temp.	Sealed in dry,Room Temperature
solubility	Dimethylformamide, DMSO (Slightly), Methanol (Slightly), Water
form	Solid
pka	3.48±0.20(Predicted)
color	Off-White to Light Beige
optical activity	[α]22/D +10°, c = 1.5 in H2O
Water Solubility	soluble
Merck	14,8001
BRN	82133
InChIKey	ODHCTXKNWHHXJC-GSVOUGTGSA-N
CAS DataBase Reference	4042-36-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36-37/39
WGK Germany	3
HS Code	29339900

MSDS Information

Provider	Language
ACROS	English
SigmaAldrich	English
ALFA	English

D-Pyroglutamic acid Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	Serves as a building block in the synthesis of diphthamide
Uses	Serves as a building block in the synthesis of diphthamide.
Definition	ChEBI: The D-enantiomer of 5-oxoproline.
Purification Methods	Purify R-pyroglutamic acid by dissolving it in H2O, filtering, passing the filtrate through Dowex 50 (H+ form), washing with H2O, pooling washings, evaporating, removing H2O azeotropically with Me2CO and *C6H6, washing the residue with Et2O and recrystallising from EtOH/pet ether. [Pradeller et al. Collect Czech Chem Commun 42 79, 80 1977, Beilstein 22/6 V 7.]

D-Pyroglutamic acid Preparation Products And Raw materials

Raw materials	5-Hydroxymethylpyrrolidin-2-one-->L-Pyroglutamic acid-->D(-)-Glutamic acid-->(-)-D-PYROGLUTAMIC ACID METHYL ESTER
Preparation Products	L-Pyroglutamic acid-->Ethanol-->(R)-(-)-1-(2-Pyrrolidinylmethyl)pyrrolidine-->FASORACETAM-->D-PYROGLUTAMIC ACID TERT-BUTYL ESTER

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