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| ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Basic information |
| Product Name: | ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate | | Synonyms: | ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate;Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate;2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylicacid ethyl ester;5-Thiazolecarboxylic acid, 2-(4-hydroxyphenyl)-4-Methyl-, ethyl ester;Intermediates of Febuxostat;ethyl 2-(4-hydroxyphenyl)-4-Methyl-5-Thiazolecarboxylate;Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate
Ethyl 2-(4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylate;2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate | | CAS: | 161797-99-5 | | MF: | C13H13NO3S | | MW: | 263.31 | | EINECS: | 605-268-8 | | Product Categories: | Febuxostat Intermediates;Febuxostat intermediate | | Mol File: | 161797-99-5.mol |
| ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Chemical Properties |
| Melting point | 180 ºC | | Boiling point | 426.8±55.0 °C(Predicted) | | density | 1.274 | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Very Slightly) | | form | Solid | | pka | 8.56±0.15(Predicted) | | color | Off-White | | CAS DataBase Reference | 161797-99-5(CAS DataBase Reference) |
| ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Usage And Synthesis |
| Uses | Ethyl 2-(4-Hydroxyphenyl)-4-methylthiazole-5-carboxylate is used in the synthesis of the major metabolites of Febuxostat (F229000), a xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout. |
| ethyl 2-(4-hydroxyphenyl)-4-methyl thiazole-5-carboxylate Preparation Products And Raw materials |
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