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| Methylglyoxal 1,1-dimethyl acetal Basic information |
| Methylglyoxal 1,1-dimethyl acetal Chemical Properties |
| Melting point | -57 °C | | Boiling point | 143-147 °C(lit.) | | density | 0.976 g/mL at 25 °C(lit.) | | vapor pressure | 11hPa at 20℃ | | refractive index | n20/D 1.398(lit.) | | Fp | 100 °F | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | form | Liquid | | color | Clear colorless to yellow | | Water Solubility | MISCIBLE | | BRN | 1560557 | | InChIKey | ULVSHNOGEVXRDR-UHFFFAOYSA-N | | CAS DataBase Reference | 6342-56-9 | | NIST Chemistry Reference | 2-Propanone, 1,1-dimethoxy-(6342-56-9) | | EPA Substance Registry System | 2-Propanone, 1,1-dimethoxy- (6342-56-9) |
| Hazard Codes | Xi | | Risk Statements | 10-36/38 | | Safety Statements | 26-36-16 | | RIDADR | UN 1224 3/PG 3 | | WGK Germany | 1 | | TSCA | Yes | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29145000 |
| Methylglyoxal 1,1-dimethyl acetal Usage And Synthesis |
| Chemical Properties | clear colorless to yellow liquid | | Uses | Pyruvic Aldehyde Dimethyl Acetal is used in the preparation of MCL1 inhibitors S63845 which is tolerable and effective in diverse cancer models. Also, acts as a synthetic reagent for the preparation of 8novel 2,4-disubstituted pyrimidines as potent, selective, and cell-permeable inhibitors of neuronal nitric oxide synthase. Selective inhibition of neuronal nitric oxide synthase is an important therapeutic approach to target neurodegenerative disorders. | | Uses | Methylglyoxal 1,1-dimethyl acetal was used in the synthesis of methylglyoxal via hydrolysis in the presence of H2SO4. It was used to investigate the effects of methylglyoxal-mediated glycation on the structure, thermal stability and enzyme activity of yeast enolase in vivo. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 41, p. 2642, 1976 DOI: 10.1021/jo00877a030 |
| Methylglyoxal 1,1-dimethyl acetal Preparation Products And Raw materials |
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