4-Hydroxypiperidine Eight Chongqing Chemdad Co. ，Ltd

Product

4-Hydroxypiperidine

CAS No.：5382-16-1

Other grades of this product :

4-Hydroxypiperidine Basic information

Product Name:	4-Hydroxypiperidine
Synonyms:	PIPERIDIN-4-OL;4-PIPERIDINOL;4PPOL;4-HYDROXYPIPERIDINE;HYDROXYPIPERIDINE(4-);AURORA KA-1006;4-Hydroxypiperidine base;4-Hydroxypiperidine, 99+%
CAS:	5382-16-1
MF:	C5H11NO
MW:	101.15
EINECS:	226-373-1
Product Categories:	Building Blocks;C5 to C7;Piperidines, Piperidones, Piperazines;Chemical Synthesis;Heterocyclic Building Blocks;Piperidines;Alcohols and Derivatives;Amines and Anilines;Pyrans, Piperidines &Piperazines;Piperidine;Heterocyclic Compounds;NADIFLOXACIN;Pyrans, Piperidines & Piperazines
Mol File:	5382-16-1.mol

4-Hydroxypiperidine Chemical Properties

Melting point	86-90 °C
Boiling point	108-114 °C/10 mmHg (lit.)
density	0.9903 (rough estimate)
vapor pressure	13Pa at 25℃
refractive index	1.4400 (estimate)
Fp	226 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	14.94±0.20(Predicted)
color	Off-White to pale Yellow
PH	11.5-11.7 (H2O)Aqueous solution
Water Solubility	soluble
Sensitive	Hygroscopic
BRN	102738
InChIKey	HDOWRFHMPULYOA-UHFFFAOYSA-N
LogP	-0.35 at 25℃
CAS DataBase Reference	5382-16-1(CAS DataBase Reference)
NIST Chemistry Reference	4-Hydroxypiperidine(5382-16-1)

Safety Information

Hazard Codes	Xi,C
Risk Statements	36/37/38-34
Safety Statements	26-36-37/39-45-36/37/39-27
RIDADR	3263
WGK Germany	3
Hazard Note	Irritant
HazardClass	8
PackingGroup	III
HS Code	29333999

MSDS Information

Provider	Language
4-Hydroxypiperidine	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Hydroxypiperidine Usage And Synthesis

Chemical Properties	yellow to yellow-orange wet solid
Uses	4-Hydroxypiperidine is used as a reagent for the synthesis of acridine (A190900) derivatives and fibrinogen receptor antagonists.
Uses	4-Hydroxypiperidine (4-Piperidinol) can be used in the synthesis of a highly potent and selective IP (PGI(2) receptor) agonist. It can also be used in the study of copper-catalyzed N- versus O-arylation.
General Description	The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor.
Flammability and Explosibility	Notclassified

4-Hydroxypiperidine Preparation Products And Raw materials

Preparation Products

2-(4-Hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxamide-->1-(5-(Hydroxymethyl)pyrimidin-2-yl)piperidin-4-ol-->1-(4-(Hydroxymethyl)-6-(trifluoromethyl)pyrimidin-2-yl)piperidin-4-ol-->Ethyl 2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylate-->2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid-->2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxamide-->Loperamide-->Ethyl 2-(4-hydroxypiperidin-1-yl)-6-(trifluoromethyl)pyrimidine-4-carboxylate-->4-Chloro-N-methylpiperidine-->1-(2-FLUORO-4-NITROPHENYL)PIPERIDIN-4-OL-->1-(5-aminopyridin-2-yl)piperidin-4-ol-->1-(Benzyloxycarbonyl)-4-piperidinone-->4-Bromopiperidine hydrobromide-->1-[5-NITROPYRIDIN-2-YL]PIPERIDINE-4-OL-->1-Boc-4-methanesulfonyloxypiperidine-->Ebastine-->1-Benzyl-4-hydroxypiperidine-->Methyl 4-hydroxypiperidine-1-carboxyl

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