| 4'-Methylbiphenyl-2-carboxylic acid Basic information |
| Product Name: | 4'-Methylbiphenyl-2-carboxylic acid |
| Synonyms: | 4'-METHYL[1,1'-BIPHENYL]-2-CARBOXYLIC ACID;2-(4-Methylphenyl)benzoic Acid 4'-Methylbiphenyl-2-carboxylic Acid;2-Carboxy-4'-methylbiphenyl, 2-(4-Methylphenyl)benzoic acid, 2-(p-Tolyl)benzoic acid;2-(p-Tolyl)benzoic Acid;1’-biphenyl]-2-carboxylicacid,4’-methyl-[;RARECHEM AL BO 0764;4'-Methyl-2-carboxybiphenyl;o-Tolylbenzoic acid |
| CAS: | 7148-03-0 |
| MF: | C14H12O2 |
| MW: | 212.24 |
| EINECS: | 230-462-0 |
| Product Categories: | Organic acids;Hypertension;INTERMEDIATESOF;Biphenyl & Diphenyl ether;C13 to C42+;Carbonyl Compounds;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Carboxylic Acids |
| Mol File: | 7148-03-0.mol |
| 4'-Methylbiphenyl-2-carboxylic acid Chemical Properties |
| Melting point | 146-148°C |
| Boiling point | 354.5±11.0 °C(Predicted) |
| density | 1.156±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO, Methanol |
| pka | 3.90±0.36(Predicted) |
| form | Solid |
| color | White |
| CAS DataBase Reference | 7148-03-0(CAS DataBase Reference) |
| EPA Substance Registry System | [1,1'-Biphenyl]-2-carboxylic acid, 4'-methyl- (7148-03-0) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HS Code | 29163990 |
| MSDS Information |
| 4'-Methylbiphenyl-2-carboxylic acid Usage And Synthesis |
| Chemical Properties | Light yellow solid |
| Uses | 4’-Methylbiphenyl-2-carboxylic Acid is used in the synthesis of angiotensin II receptor antagonists used as potent orally active antihypertensives. |
| General Description | 4′-Methyl-2-biphenylcarboxylic acid (4′-Methyl-bi-phenyl-2-carboxyl-ic acid) can be synthesized by reacting 4′-methylbiphenyl-2-carbonitrile with methanol and 30% NaOH solution. Its crystal structure has been characterized by the centrosymmetric hydrogen-bonded dimers. |
| Purification Methods | Crystallise the acid from toluene or *C6H6 (m 147-148o). [Beilstein 9 H 677, 9 IV 2523.] |
| 4'-Methylbiphenyl-2-carboxylic acid Preparation Products And Raw materials |
| Preparation Products | Methyl 4'-methylbiphenyl-2-carboxylate-->4-BROMOMETHYLBIPHEBYL-2'-CARBOXYLIC ACID |
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