N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Eight Chongqing Chemdad Co. ，Ltd

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N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide

CAS No.：90357-51-0

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N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Basic information

Product Name:	N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide
Synonyms:	N-[4-CYANO-3-(TRIFLUOROMETHYL)PHENYL]METHACRYLAMIDE EPOXIDE (INTERMEDIATE OF BICALUTAMIDE);4’-Cyano-3’-trifluoromethyl-2,3-epoxy-2-methylpropioanilide;N-[4-Cyano-3-(Trifluoromethyl)Phenyl]-2-Methyloxiranecarboxamide ( For Bicalutamide );N-[4-Cyano-3-(trifluoroMethyl)phenyl]MethacrylaMid;N-[4-Cyano-3-(triflu;n-[4-cyano-3-(trifluoromethyl)phenyl]-2-methyloxirane-2-carboxamide;N-4-CYANO-3-(TRIFLUOROMETHYL)PHENYLMETHACRYLAMIDE EPOXIDE;1,2-EPOXY-2-METHYL-N-[4-CYANO-3-(TRIFLUOROMETHYL)]
CAS:	90357-51-0
MF:	C12H9F3N2O2
MW:	270.21
EINECS:	618-536-4
Product Categories:	Bicalutamide;API intermediates;Chemical intermediate for Bicalutamide
Mol File:	90357-51-0.mol

N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Chemical Properties

Melting point	151-152 °C
Boiling point	436.4±45.0 °C(Predicted)
density	1.42±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	12.08±0.70(Predicted)
color	White to Off-White
CAS DataBase Reference	90357-51-0(CAS DataBase Reference)

Safety Information

Safety Statements	24/25
HS Code	29269090

MSDS Information

N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Usage And Synthesis

Uses	N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methyl-2-oxiranecarboxamide, is an intermediate in synthesis of more complex pharmaceutical compounds. It is used in the synthesis of potential impurities of Bicalutamide (B382000), which is an oral nonsteroidal, anti-androgen drug used for prostate cancer.

N-[4-Cyano-3-(trifluoromethyl)phenyl]methacrylamide epoxide Preparation Products And Raw materials

Raw materials

3-chloro-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide-->Propanamide, N-[4-cyano-3-(trifluoromethyl)phenyl]-2,3-dihydroxy-2-methyl--->(R)-3-broMo-N-(4-cyano-3-trifluoroMethylphenyl)-2-hydroxy-2-MethylpropionaMide-->Benzonitrile, 4-isocyanato-2-(trifluoroMethyl)--->4-Fluoro-2-trifluoromethylbenzonitrile-->2-Methyloxirane-2-carboxylic acid-->N-[4-Cyano-3-(trifluoromethyl)phenyl]-2-methacrylamide-->4-Amino-2-(trifluoromethyl)benzonitrile-->1-Naphthol

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