1-(2-Chloroethyl)pyrrolidine Hydrochloride Eight Chongqing Chemdad Co. ，Ltd

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1-(2-Chloroethyl)pyrrolidine Hydrochloride

CAS No.：7250-67-1

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1-(2-Chloroethyl)pyrrolidine Hydrochloride Basic information

Product Name:	1-(2-Chloroethyl)pyrrolidine Hydrochloride
Synonyms:	1-(2-chloroethyl)-pyrrolidinhydrochloride;1-(2-CHLOROETHYL)PYRROLIDINE HCL;2-PYRROLIDINOETHYL CHLORIDE HYDROCHLORIDE;2-CHLOROETHYLPYRROLIDINE HYDROCHLORIDE;2-CHLOROETHYLPYRROLIDINE HCL;2-(N-Pyrrolidino)ethyl chloride hydrochloride;N-(2-Chloroethyl)pyrrolidine HCl;N-Chloroethylpyrprolidine
CAS:	7250-67-1
MF:	C6H13Cl2N
MW:	170.08
EINECS:	230-660-7
Product Categories:	organic synthesis and intermediates;Pharmaceutical raw materials;Pyrrole&Pyrrolidine&Pyrroline
Mol File:	7250-67-1.mol

1-(2-Chloroethyl)pyrrolidine Hydrochloride Chemical Properties

Melting point	167-170 °C(lit.)
Boiling point	237°C(lit.)
density	0.4[at 20℃]
vapor pressure	1.64hPa at 25℃
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Water (Slightly)
form	Crystalline Powder or Crystals
color	White to off-white
Water Solubility	Soluble
Sensitive	Hygroscopic
BRN	3677061
InChI	InChI=1S/C6H12ClN.ClH/c7-3-6-8-4-1-2-5-8;/h1-6H2;1H
InChIKey	FSNGFFWICFYWQC-UHFFFAOYSA-N
SMILES	N1(CCCl)CCCC1.[H]Cl
LogP	0.736 at 25℃
CAS DataBase Reference	7250-67-1(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-20/22
Safety Statements	26-36-37/39
WGK Germany	3
RTECS	UY0703150
HS Code	29339900

MSDS Information

Provider	Language
2-Pyrrolidinoethyl chloride hydrochloride	English
ACROS	English
SigmaAldrich	English
ALFA	English

1-(2-Chloroethyl)pyrrolidine Hydrochloride Usage And Synthesis

Chemical Properties	white to off-white crystals or crystalline powder
Uses	1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine used in the preparation of various pharmaceutical compound such as the estrogen receptor antagonist Nafoxidine (N212800) and its ana logues.
Uses	1-(2-Chloroethyl)pyrrolidine is a haloalkyl substituted pyrrolidine used in the preparation of various pharmaceutical compound such as the estrogen receptor antagonist Nafoxidine (N212800) and its analogues.
Purification Methods	Purify the hydrochloride by recrystallisation from isopropanol/di-isopropyl ether (charcoal) and recrystallise it twice more. The free base, b 55-56o/11mm, 60-63o/23mm and 90o/56mm, is relatively unstable and should be converted to the hydrochloride immediately, by dissolving in isopropanol and bubbling dry HCl through the solution at 0o, filtering off the hydrochloride and recrystallising it. The picrate has m 107.3-107.8o (from EtOH) [Cason J Org Chem 24 247 1959, Wright et al. J Am Chem Soc 70 3098 1948]. [Beilstein 20 III/IV 66.]

1-(2-Chloroethyl)pyrrolidine Hydrochloride Preparation Products And Raw materials

Raw materials

Hydrochloric acid-->Sulfuric acid-->Dichloromethane-->Thionyl chloride-->Potassium carbonate-->Chloroform-->Acetonitrile-->Isopropyl alcohol-->2-Chloroethanol-->Pyrrolidine-->Diisopropyl ether-->N-(2-Hydroxyethyl)pyrrolidine

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