tert-butyl N-[(3S)-pyrrolidin-3-yl]carbamate Eight Chongqing Chemdad Co. ，Ltd

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tert-butyl N-[(3S)-pyrrolidin-3-yl]carbamate

CAS No.：122536-76-9

Other grades of this product :

(S)-3-(Boc-amino)pyrrolidine Basic information

Product Name:	(S)-3-(Boc-amino)pyrrolidine
Synonyms:	CARBAMIC ACID, (3S)-3-PYRROLIDINYL-, 1,1-DIMETHYLETHYL ESTER;BOC-(3S)-(-)-3-AMINOPYRROLIDINE;BOC-(3S)-(-)-(3)APYROLIDI;(S)-3-(Boc-amino)pyrrolidine (3SR)-(+)-(tert-Butoxycarbonylamino)pyrrolidine;(3SR)-(+)-(tert-Butoxycarbonylamino)pyrrolidine;(3S)-(-)-3-(BOC-AMINO)PYRROLIDINE;(3S)-(-)-3-(T-BUTOXYCARBONYLAMINO)PYRROLIDINE;(3S)-(-)-3-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE
CAS:	122536-76-9
MF:	C9H18N2O2
MW:	186.25
EINECS:	628-488-6
Product Categories:	3-Aminopyrrolidines;Amines (Chiral);Benzenes;Chiral 3-Aminopyrrolidines;Chiral Building Blocks;Synthetic Organic Chemistry;N-BOC;Imidazoles, Pyrroles, Pyrazoles, Pyrrolidines;pharmacetical;Pyrrole&Pyrrolidine&Pyrroline;API intermediates
Mol File:	122536-76-9.mol

(S)-3-(Boc-amino)pyrrolidine Chemical Properties

Melting point	50 °C
Boiling point	112°C/0.25mm
density	1.04±0.1 g/cm3(Predicted)
refractive index	-20 ° (C=1, EtOH)
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	12.37±0.20(Predicted)
form	Powder
color	White to off-white
optical activity	[α]/D -21.5±2.0°, c = 1 in ethanol
Water Solubility	Soluble in water.
Sensitive	Air Sensitive
BRN	5377813
CAS DataBase Reference	122536-76-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,C
Risk Statements	36/37/38
Safety Statements	26
RIDADR	3259
WGK Germany	3
F	10-23
HazardClass	8
PackingGroup	III
HS Code	29339900

MSDS Information

Provider	Language
tert-Butyl-(S)-3-pyrrolidinylcarbamate	English
SigmaAldrich	English
ALFA	English

(S)-3-(Boc-amino)pyrrolidine Usage And Synthesis

Chemical Properties	White crystalline powder
Uses	(S)-3-(Boc-amino)pyrrolidine can be used as a building block to prepare: 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as potent inhibitors against EGFR tyrosine kinase. Aminopyrrolidine scaffolds for asymmetric Morita?Baylis-Hillman reaction. N-benzyl-3-sulfonamidopyrrolidines as potent bacterial cell division inhibitors.

(S)-3-(Boc-amino)pyrrolidine Preparation Products And Raw materials

Raw materials

Methanol-->Triethylamine-->Ammonium hydroxide-->Sodium borohydride-->Di-tert-butyl dicarbonate-->Calcium chloride-->Methanesulfonyl chloride-->L-Aspartic acid-->Carbamic acid, N-[(1S)-3-[(methylsulfonyl)oxy]-1-[[(methylsulfonyl)oxy]methyl]propyl]-, 1,1-dimethylethyl ester-->Carbamic acid, [1-(2-propenyl)-3-pyrrolidinyl]-, 1,1-dimethylethyl ester, (S)- (9CI)-->1-CBZ-3-BOC-AMINO PYRROLIDINE-->1-AMINOPYRROLIDINE-->(S)-(-)-1-BENZYL-3-(BOC-AMINO)PYRROLIDINE-->(S)-1-N-CBZ-3-N-BOC-AMINO PYRROLIDINE-->(S)-(-)-2-(Boc-Amino)-1,4-butanediol

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