| Stanolone Basic information |
| Product Name: | Stanolone |
| Synonyms: | (5S,8R,9S,10S,13S,14S,17S)-17-Hydroxy-10,13-dimethyltetradecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one;5α-androstan-17β-ol-3-one solution,100ppm;(8R,9S,10S,13S,14S)-17-hydroxy-10,13-dimethyl-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one;(5-alpha,17-beta)-17-hydroxyandrostan-3-one;(5alpha,17beta)-17-Hydroxy-androstan-3-one;17beta-Hydroxy-3-androstanone;17-beta-hydroxy-5-alpha-androstan-3-on;17-hydroxy-,(5-alpha,17-beta)-androstan-3-on |
| CAS: | 521-18-6 |
| MF: | C19H30O2 |
| MW: | 290.45 |
| EINECS: | 208-307-3 |
| Product Categories: | API;Intermediates & Fine Chemicals;Steroids;Pharmaceuticals;Steroid and Hormone |
| Mol File: | 521-18-6.mol |
| Stanolone Chemical Properties |
| Melting point | 178-183 °C |
| alpha | 27 º |
| Boiling point | 372.52°C (rough estimate) |
| density | 1.0320 (rough estimate) |
| refractive index | 1.4709 (estimate) |
| Fp | 9℃ |
| storage temp. | 2-8°C |
| pka | 15.08±0.60(Predicted) |
| form | neat |
| Water Solubility | 344.3g/L(temperature not stated) |
| Merck | 13,8872 |
| BRN | 2056371 |
| InChIKey | NVKAWKQGWWIWPM-ABEVXSGRSA-N |
| CAS DataBase Reference | 521-18-6(CAS DataBase Reference) |
| NIST Chemistry Reference | Stanolone(521-18-6) |
| EPA Substance Registry System | Androstan-3-one, 17-hydroxy-, (5.alpha.,17.beta.)- (521-18-6) |
| Safety Information |
| Hazard Codes | Xn,T,F |
| Risk Statements | 61-40-39/23/24/25-23/24/25-11 |
| Safety Statements | 53-36/37/39-45-36/37-16 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | BV8052000 |
| MSDS Information |
| Provider | Language |
|---|---|
| 4-Dihydrotestosterone | English |
| SigmaAldrich | English |
| Stanolone Usage And Synthesis |
| Description | Stanolone is well known as dihydrotestosterone (DHT), which is an endogenous androgen sex steroid and hormone. It is an agonist of the androgen receptor (AR). It plays important physiological role in sexual differentiation, maturation of the penis and scrotum, hair, sebum production and development and maintenance of the prostate gland and seminal vesicles. It is mainly used for the treatment of male hypogonadism, androgen deficiency of severe illness, androgen deficiency of ageing and microphallus in infancy. |
| Chemical Properties | White Crystalline Solid |
| Originator | Neodrol,Pfizer,US,1953 |
| Uses | Stanolone is a potent androgenic metabolite of testosterone that It is Controlled substance. It was created for the treatment of muscle wasting disease, and osteoporosis. It is a powerful anabolic steroid, which is similar to the body's naturally produced Dihydrotestosterone. Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. |
| Definition | ChEBI: Stanolone is a 17beta-hydroxy steroid that is testosterone in which the 4,5 double bond has been reduced to a single bond with alpha-configuration at position 5. It has a role as an androgen, a human metabolite, a Daphnia magna metabolite and a mouse metabolite. It is a 17beta-hydroxy steroid, a 17beta-hydroxyandrostan-3-one and a 3-oxo-5alpha-steroid. It derives from a hydride of a 5alpha-androstane. |
| Manufacturing Process | A solution of 1.0 g of 3,17-androstandione in 50 ml of methanol and containing 1 g of selenium dioxide, was allowed to remain in an ice-chest overnight. The formed 3,3-dimethoxyandrostan-17-one was not separated. 1 g of solid potassium hydroxide and 2.5 g of sodium borohydride in 2.5 ml of water were added and the mixture allowed to react at room temperature for 24 hours. The solution was then poured into a large excess of water, extracted with methylene chloride, the organic layer dried and evaporated to a residue. The residue was dissolved in ether, and a small amount of selenium removed by filtration. The ether was boiled off and the organic material dissolved in 100 ml of boiling acetone. 25 ml of diluted hydrochloric acid were added, the solution boiled for 5 minutes and then allowed to cool. Upon crystallization, 0.85 g of androstan-17β-ol-3-one was obtained, melting point 175°C to 178°C. |
| Therapeutic Function | Androgen |
| General Description | Dihydrotestosterone (Item No. 15874) is an analytical reference standard categorized as an anabolic androgenic steroid. Anabolic steroids, including dihydrotestosterone, have been used to enhance physical performance in athletes. Dihydrotestosterone is regulated as a Schedule III compound in the United States. This product is intended for research and forensic applications. |
| References | https://en.wikipedia.org/wiki/Dihydrotestosterone#Medical_use Swerdloff, R. S., and C. Wang. "Dihydrotestosterone: a rationale for its use as a non-aromatizable androgen replacement therapeutic agent."Baillieres Clin Endocrinol Metab 12.3(1998):501. |
| Stanolone Preparation Products And Raw materials |
| Raw materials | Selenium dioxide-->Sodium borohydride |
| Preparation Products | 5ALPHA-ANDROST-16-EN-3-ONE |
Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.
日本语
한국어
Français
Deutsch
España
Türkiye