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| TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Basic information |
| Product Name: | TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA | | Synonyms: | [(+)-BIOTIN-PEG12-NHS ESTER];H2N-PEG3-CH2CH2-t-butylester;tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate;Amino-PEG3-COOtBu;TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA;H2N-PEG3-tBu;H2N-PEG3-CH2CH2COOtBu;tert-Butyl 12-aMino-4,7,10-trioxa-dodec | | CAS: | 252881-74-6 | | MF: | C13H27NO5 | | MW: | 277.36 | | EINECS: | | Product Categories: | PEG-COOtBu;peg | | Mol File: | 252881-74-6.mol |
| TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Chemical Properties |
| Boiling point | 358.5±27.0 °C(Predicted) | | density | 1.029±0.06 g/cm3(Predicted) | | Fp | 169.7 °C | | storage temp. | -20°C | | pka | 8.74±0.10(Predicted) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 | | F | 10-34 | | HS Code | 2922500090 |
| TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Usage And Synthesis |
| Description | Amino-PEG3-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:- Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.
- Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.
- Synthesis of polycationic adamantane-based dendrons for cell imaging.
- Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).
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| TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA Preparation Products And Raw materials |
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