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| 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Basic information |
| Product Name: | 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate | | Synonyms: | 2,6-Diazaspiro[3.3]heptane, N2-BOC protected hemioxalate;2,6-Diazaspiro[3.3]heptane-2-carboxylic acid ethanedioate, 1,1-dimethylethyl ester;tert-butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate oxalate;2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester heMioxylate;2,6-Diazaspiro[3.3]heptane-2-carboxylic acid, 1,1-diMethylethyl ester, ethanedioate (2:1);1-Boc-2,6-diazaspiro[3.3]heptane heMioxalate, 97%;tert-Butyl 2,6-diazaspiro[3.3]heptane-2-carboxylate, hemioxalate salt;2,6-Diazaspiro[3.3]heptane-2-carboxylic acid, 1,1-diMethylethyl ester, heMioxalate | | CAS: | 1041026-71-4 | | MF: | C22H38N4O8 | | MW: | 486.56 | | EINECS: | | Product Categories: | | Mol File: | 1041026-71-4.mol |
| 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Chemical Properties |
| Melting point | 206-209℃ | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | DMSO (Slightly, Heated), Methanol (Slightly, Sonicated) | | form | Solid | | color | White to Off-White | | Water Solubility | Slightly soluble in water. | | Stability: | Hygroscopic |
| 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Usage And Synthesis |
| Chemical Properties | white to yellow Solid. | | Uses | It is employed as a intermediate for pharmaceutical. | | Uses | 2,6-Diazaspiro[3.3]heptane-2-carboxylic Acid tert-Butyl Ester Hemioxylate is preparation of pyrimidine derivatives and related heterocycles as CDK inhibitors for treatment of diseases. | | Preparation | Synthesis of 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate: Take a 500mL single-necked bottle, add 6-toluenesulfonyl-2,6-diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester (7g, 20mmol), dissolve in methanol (200mL), add magnesium chips (3.84 g) g, 0.16 mol, 8 equiv) and stirred at room temperature. The reaction solution gradually turned into a white viscous state with the dissolution of the magnesium scraps, and TLC showed that the reaction of the raw materials was completed. The solvent was removed by rotary evaporation, ether (150 mL) was added, stirred at room temperature for 1 h, filtered through celite, the filtrate was dried over anhydrous sodium sulfate, and an ethanol solution (3 mL) of anhydrous oxalic acid (0.89 g, 9.9 mmol, 0.5 equiv) was added dropwise, A white precipitate appeared immediately, which was filtered under reduced pressure to give 3.2 g of a colorless solid, 82%. |
| 2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate Preparation Products And Raw materials |
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![2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate](/img/1041026-71-4.jpg "2,6-Diazaspiro[3.3]heptane-2-carboxylic acid tert-butyl ester hemioxylate")
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