| 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Basic information |
| Product Name: | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol |
| Synonyms: | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol;3,3,-(2,4-diaminopteridine-6,7-diyl)diphenol;TG100-115;TG100115;TG100 115;6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine;3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol TG100-115;TG100-115, >=98%;TG100115; TG100 115;CS-427 |
| CAS: | 677297-51-7 |
| MF: | C18H14N6O2 |
| MW: | 346.34 |
| EINECS: | |
| Product Categories: | Inhibitors;Akt;mTOR;PI3K;APIs |
| Mol File: | 677297-51-7.mol |
| 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Chemical Properties |
| Boiling point | 699.6±65.0 °C(Predicted) |
| density | 1.516±0.06 g/cm3(Predicted) |
| solubility | insoluble in H2O; insoluble in EtOH; ≥3.46 mg/mL in DMSO |
| form | Yellow powder solid. |
| pka | 8.54±0.10(Predicted) |
| Safety Information |
| MSDS Information |
| 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Usage And Synthesis |
| Uses | TG100-115 is a potent and selective phosphoinositide 3-kinase gamma/delta (PI3Kγ/δ) inhibitor. It can provide potent cardioprotection, reduce infarct development, and preserve myocardial function. |
| Biological Activity | tg100-115 is an inhibitor of pi3kγ and pi3kδ with ic50 values of 83 nm and 235 nm, respectively. tg100-115 shows no obvious activity against pi3kα and pi3kβ [1].tg100-115 remarkably reduced eosinophil accumulation, balf levels of classic th2 cytokine il-13, perivascular and peribronchial leukocyte accumulations, and bronchiolar mucin accumulation in a murine model. besides, tg100-115 showed to reduce airway hyper-responsiveness (ahr) by approximately 50% in asthmatic mice. moreover, tg100-115 has been reported to reduce both smoke-and lps-induced neutrophil and lps-induced classic th1 cytokine tnfα accumulations in mice [2]. |
| references | [1] doukas j1, wrasidlo w, noronha g, dneprovskaia e, fine r, weis s, hood j, demaria a, soll r, cheresh d. hosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. proc natl acad sci u s a. 2006 dec 26;103(52):19866-71.[2] doukas j1, eide l, stebbins k, racanelli-layton a, dellamary l, martin m, dneprovskaia e, noronha g, soll r, wrasidlo w, acevedo lm, cheresh da. aerosolized phosphoinositide 3-kinase gamma/delta inhibitor tg100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. j pharmacol exp ther. 2009 mar;328(3):758-65. |
| 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Preparation Products And Raw materials |
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