![7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE](/img/160129-45-3.jpg "7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE")
| 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE Basic information |
| Product Name: | 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE |
| Synonyms: | 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE;7-chloro-1, 2, 3, 4-benzo [b] AZA Zhuo-5-ketone;7-Chloro-1,2,3,4-tetrahydro-5H-1-benzozepin-5-one;7-chloro-1,2,3,4-tetrahydro-1-benzazepin-5-one;Tolvaptan Impurity 29;5H-1-Benzazepin-5-one,7-chloro-1,2,3,4-tetrahydro-;7-Chlorobenzo[b]azepan-5-one;7-chloro-2,3,4,5-tetrahydro-1H-1-benzazepin-5-one |
| CAS: | 160129-45-3 |
| MF: | C10H10ClNO |
| MW: | 195.65 |
| EINECS: | 690-079-3 |
| Product Categories: | Building Blocks/Intermediates;Tolvaptan intermediate |
| Mol File: | 160129-45-3.mol |
| 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE Chemical Properties |
| Melting point | 103.0 to 107.0 °C |
| Boiling point | 356.5±41.0 °C(Predicted) |
| density | 1.234±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 2.36±0.20(Predicted) |
| color | Off-White to Pale Yellow |
| Safety Information |
| Hazard Codes | T |
| Risk Statements | 25 |
| Safety Statements | 45 |
| HS Code | 2933998090 |
| MSDS Information |
| 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE Usage And Synthesis |
| Chemical Properties | White Solid |
| Uses | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of Tolvaptan (T536650) (OPC-41061), an orally active nonpeptide arginine vasopressin V2 receptor antagonist |
| Uses | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one is an intermediate in the synthesis of 7-Chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl-amino)benzoyl]-2,3,4,5 -tetrahydro-1H-1-benzazepine (OPC-41061) , an orally active nonpeptide arginine vasopressin V2 receptor antagonist |
| 7-CHLORO-1,2,3,4-TETRAHYDRO-BENZO[B]AZEPIN-5-ONE Preparation Products And Raw materials |
| Preparation Products | N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide |
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