2-(Trimethylsilyl)ethoxymethyl chloride
2-(Trimethylsilyl)ethoxymethyl chloride
  • CAS No.:76513-69-4
Other grades of this product :
boiling point170-172 °C (lit.) 57-59 °C/8 mmHg (lit.)
density0.942 g/mL at 25 °C (lit.)
Refractive indexn20/D 1.435(lit.)
flash point116 °F
Storage conditions2-8°C
solubilitySol most organic solvents (pentane, CH2Cl2, Et2O, THF, DMF, DMPU, HMPA)
formLiquid
proportion0.95
colourClear colorless
Water solubilitydecomposes
Hydrolysis sensitivity7: reacts slowly with moisture/water
BRN3587289
InChIKeyBPXKZEMBEZGUAH-UHFFFAOYSA-N
CAS76513-69-4


2-(Chloromethoxy)ethyltrimethylsilane is used in the preparation of SEM [2-(trimethylsilyl)ethoxy]methyl]-ethers. It serves as a phenol protecting group in the synthesis of laterifluorones. Further, it reacts with 1H-imidazole to prepare 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole.

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