| 3-Amino-5-fluoropyridine Basic information |
| Product Name: | 3-Amino-5-fluoropyridine |
| Synonyms: | 3-AMINO-5-FLUOROPYRIDINE;3-Pyridinamine,5-fluoro-(9CI);3-AMINO-5-FLUOROPYRIDINE 97%;5-Fluoropyridin-3-amine;5-Fluoropyridin-3-ylamine;3-Amine-5-fluoro-pyridin;3-AMine-5-fluoro-pyridine;3-PyridinaMine,5-fluoro- |
| CAS: | 210169-05-4 |
| MF: | C5H5FN2 |
| MW: | 112.11 |
| EINECS: | 664-255-5 |
| Product Categories: | Fluorine series;Building Blocks;C5;C5 to C6;Chemical Synthesis;Fluorinated Building Blocks;PYRIDINE;Pyridine series;Pyridines;Boronic Acid;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocyclic Fluorinated Building Blocks;Other Fluorinated Heterocycles;AMINEPRIMARY;HALIDE |
| Mol File: | 210169-05-4.mol |
| 3-Amino-5-fluoropyridine Chemical Properties |
| Melting point | 86°C |
| Boiling point | 232.7±20.0 °C(Predicted) |
| density | 1.257±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| form | powder to crystal |
| pka | 3.74±0.20(Predicted) |
| color | Light orange to Yellow to Green |
| CAS DataBase Reference | 210169-05-4(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,Xn |
| Risk Statements | 20/21/22-36/37/38-22 |
| Safety Statements | 26-36-36/37 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 2933399990 |
| MSDS Information |
| 3-Amino-5-fluoropyridine Usage And Synthesis |
| Chemical Properties | Light yellow Crystal |
| Uses | 3-amino-5-fluoropyridine is an important intermediate mainly used in medicine and organic synthesis. It is used to synthesize Ivosidenib. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults. |
| Application | Reactant for:Preparation of nonpeptide inhibitors of measles virus entry. |
| Preparation | synthesis of 3-Amino-5-fluoropyridine: A solution of 3-amino-2,4,6-tribromo-5-fluoropyridine (23c) (0.9 g, 2.6 mmol), triethylamine (1.1 cm3, 7.9 mmol), palladium catalyst (0.1 g of 5% Pd-C catalyst) and DCM (15 cm3) was hydrogenated on a Parr apparatus for 18 h. Water (20 cm3) was added and the mixture filtered and extracted into DCM. The DCM solution was dried (MgS04) and evaporated giving 3-amino-5-fluoropyridine (0.3 g, >95% ), m.p. 86 ·c (from DCM) (Found: C, 53.6; H, 4.6; N, 25.0. C5H5FN2 requires C, 53.6; H, 4.5 N, 25.0%);IR spectrum no. 9; mass spectrum no. 5; nmr spectrum no. 29. |
| 3-Amino-5-fluoropyridine Preparation Products And Raw materials |
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