| 1-(4-Chlorobenzhydryl)piperazine Basic information |
| Product Name: | 1-(4-Chlorobenzhydryl)piperazine |
| Synonyms: | 1-((4-chlorophenyl)phenylmethyl)-piperazin;1-(4-CHLOROBENZYLHYDRYL) PIPERAZINE;(1-(p-Chloro- -phenylbenzyl)-piperazine;Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-;NSC 86164;1-(4-Chloro-a-phenylbenzyl)piperazine;4-(α-Piperazinobenzyl)phenyl chloride;1-(4-Chlorobenzhydry)piperazine |
| CAS: | 303-26-4 |
| MF: | C17H19ClN2 |
| MW: | 286.8 |
| EINECS: | 206-137-4 |
| Product Categories: | C15 to C30;Building Blocks;C16 to C29;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Piperazine derivates;API intermediates;Aromatics;Metabolites & Impurities;Building Blocks;Halogenated Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Heterocycles;Heterocyclic Building Blocks;Piperazines;PiperazinesHeterocyclic Building Blocks |
| Mol File: | 303-26-4.mol |
| 1-(4-Chlorobenzhydryl)piperazine Chemical Properties |
| Melting point | 65-70 °C (lit.) |
| Boiling point | 178-180 °C/0.5 mmHg (lit.) |
| density | 1.0912 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5749 (estimate) |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | soluble in Methanol |
| form | Crystalline Powder |
| pka | 8.99±0.10(Predicted) |
| color | White to light beige |
| Water Solubility | 144.6mg/L at 25℃ |
| LogP | 3.4 at 25℃ |
| CAS DataBase Reference | 303-26-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-(303-26-4) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-37/39-24/25 |
| WGK Germany | 3 |
| RTECS | TL1772000 |
| Hazard Note | Irritant |
| HS Code | 29339900 |
| MSDS Information |
| Provider | Language |
|---|---|
| 1-(4-Chlorobenzhydryl)piperazine | English |
| SigmaAldrich | English |
| ACROS | English |
| 1-(4-Chlorobenzhydryl)piperazine Usage And Synthesis |
| Chemical Properties | White Solid |
| Uses | A metabolite of Cetirizine (C281100) and Hydroxyzine. Citirizine impurity A. |
| Uses | Cetrizine Dihydrochloride intermediate |
| Preparation | Preparation of 1-[(4-chlorophenyl)phenylmethyl]piperazine. (CPMP)About 0.5 mL of DMF, 0.1 g of KI and 10 g (0.12 mol) of piperazine were mixed with 15 mL of toluene and heated to 80oC for 0.5 h. This mixture at 80oC was mixed with 4-CBC in toluene and the temperature was maintained at 80oC for a period of 2 h followed by refluxing at the same temperature for 12h. The reaction mixture was then cooled to 20oC. The toluene layer was washed twice with 20 mL of water and treated with HCl (15 mL conc. HCl in 5mL of water) at 5-10oC. The reaction mixture was filtered and the aqueous layer was separated from the filtrate. About 10 mL of toluene and 10 mL of methylene dichloride (MDC) washes were given to the aqueous layer and neutralized with 22 mL of 30 % NaOH solution at 10oC and maintained at 20oC for 2h. The solid compound formed was filtered, sucked and dried at 50oC for 3 h.Yield: 92 %; m.p: 63-65oC. |
| Flammability and Explosibility | Notclassified |
| Safety Profile | An experimental teratogen.Experimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and Clí. |
| 1-(4-Chlorobenzhydryl)piperazine Preparation Products And Raw materials |
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