| Semicarbazide Basic information |
| Product Name: | Semicarbazide |
| Synonyms: | Aminomocovina;amino-ure;Carbamic acid, hydrazide;carbamicacid,hydrazide;carbamoyl-hydrazin;Carbamylhydrazine;Carbazamide;Hydrazine, carbamoyl- |
| CAS: | 57-56-7 |
| MF: | CH5N3O |
| MW: | 75.07 |
| EINECS: | 200-339-6 |
| Product Categories: | Pharmaceutical Intermediates;HydrazidesSupported Synthesis;Derivatization Reagents HPLC;Fluorescence;Scavengers;Silica Gel |
| Mol File: | 57-56-7.mol |
| Semicarbazide Chemical Properties |
| Melting point | 96°C |
| Boiling point | 133.71°C (rough estimate) |
| density | 1.286±0.06 g/cm3(Predicted) |
| refractive index | 1.4451 (estimate) |
| pka | pK1:3.53(+1) (25°C,μ=0.1) |
| CAS DataBase Reference | 57-56-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Hydrazinecarboxamide-(57-56-7) |
| EPA Substance Registry System | Semicarbazide (57-56-7) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22 |
| WGK Germany | 3 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Semicarbazide Usage And Synthesis |
| Description | Semicarbazide (SM) is a metabolite of the nitrofurane Nitrofurazone (5-nitro-2- furaldehyde-semicarbazone), used as indicator to detect the use of nitrofurazone in food-producing animals due to their carcinogenic properties the use of nitrofurans is prohibited within the EU in animal breeding (Commission Regulation 37/2010) . to harmonise the detection of semicarbazide a Minimum Required Performance Limit (MRPL) of 1 µg/kg is set within the EU (Commission Decision 2003/181). |
| Definition | ChEBI: A monocarboxylic acid amide that is urea where one of the amino groups has been replaced with hydrazine. |
| Toxicology | Limited toxicological data are available for semicarbazide. It belongs, however, to a family of chemicals (hydrazines) which are known to cause cancer in animals. Semicarbazide is weakly genotoxic in some in vitro tests. The limited in vivo experimental data available are insufficient to assess whether the activity observed in vitro is also expressed in vivo. Semicarbazide appears to be only a weak carcinogen. |
| Semicarbazide Preparation Products And Raw materials |
| Raw materials | Urea-->Hydrazine sulfate-->Sodium cyanate-->Semicarbazide hydrochloride |
| Preparation Products | Hydrocortisone-->4'-Methylacetophenone-->Semicarbazide hydrochloride-->CIVETONE-->2,6-Dihydroxypurine-->Nitrofurantoin-->Menthone-->Muscone-->Mitoguazone-->4-Phenylurazole-->ACETONE SEMICARBAZONE |
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