| 6-Chloronicotinic acid Basic information |
| Product Name: | 6-Chloronicotinic acid |
| Synonyms: | RARECHEM AL BO 0729;TIMTEC-BB SBB004004;3-Pyridinecarboxylic acid, 6-chloro-;6-chloro-3-pyridinecarboxylicaci;6-CHLORONICOTINIC ACID;6-CHLORO-3-PYRIDINECARBOXYLIC ACID;6-Chloronicotinic acid, 99% 25GR;6-Chloronicotinic acid, 99% 5GR |
| CAS: | 5326-23-8 |
| MF: | C6H4ClNO2 |
| MW: | 157.55 |
| EINECS: | 226-201-5 |
| Product Categories: | pyridine series;Picolinic acid series;Carboxylic Acids;Organic acids;Chloropyridines;Halopyridines;Nitrogen cyclic compounds;blocks;Carboxes;Pyridines;Pyridine;Carboxylic Acids;Building Blocks;C5 to C6;C6 to C7;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;C6;carboxylic acid| alkyl chloride |
| Mol File: | 5326-23-8.mol |
| 6-Chloronicotinic acid Chemical Properties |
| Melting point | 190 °C (dec.)(lit.) |
| Boiling point | 241.15°C (rough estimate) |
| density | 0.5 |
| refractive index | 1.5870 (estimate) |
| Fp | 192°C |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | deionized water: soluble |
| form | Crystalline Powder |
| pka | 3.24±0.10(Predicted) |
| color | Off-white to beige |
| Water Solubility | Soluble in water (2 mg/ml at 20°C), ethanol, methanol, DMSO, and slightly soluble in chloroform. |
| Decomposition | 192 ºC |
| BRN | 115993 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | UAWMVMPAYRWUFX-UHFFFAOYSA-N |
| CAS DataBase Reference | 5326-23-8(CAS DataBase Reference) |
| NIST Chemistry Reference | 6-Chloronicotinic acid(5326-23-8) |
| EPA Substance Registry System | 6-Chloronicotinic acid (5326-23-8) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-24/25-37/39 |
| WGK Germany | 3 |
| TSCA | T |
| HazardClass | IRRITANT |
| HS Code | 29333999 |
| MSDS Information |
| Provider | Language |
|---|---|
| 6-Chloronicotinic acid | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| 6-Chloronicotinic acid Usage And Synthesis |
| Chemical Properties | Off-white to beige crystalline powder |
| Uses | 6-Chloronicotinic acid is used as building block for different chemical synthesis. It is an intermediate for the synthesis of N-(thiophen-2-yl) benzamide derivatives as BRAFV600E inhibitors, and novel DNA-gyrase B inhibitors. |
| Uses | 6-Chloropyridine-3-carboxylic acid (6-chloronicotinic acid/6-CNA) has been used to study its photolytic and photocatalytic degradation. 6-CNA is a degradation product of neonicotinoid insecticides imidacloprid and acetamiprid and is known to appear in different environmental matrices. The product has been used as a media component during the isolation of 6-CNA degrading bacterial strain from imidacloprid-exposed soil samples. |
| Definition | ChEBI: 6-Chloronicotinic acid is a member of pyridines and an aromatic carboxylic acid. |
| General Description | 6-Chloropyridine-3-carboxylic acid is a metabolite of the neonicotinoid pesticides, imidacloprid and acetamiprid and occurs in different environmental matrices.(3) It is widely used in agricultural crop protection, domestic insect control and environmental pest management. |
| Purification Methods | Purify it by recrystallisation from hot H2O and sublime it in a vacuum. [Pechmann & Welsch Chem Ber 17 2384 1884, Herz & Murty J Org Chem 26 122 1961, Beilstein 22/2 V 177.] |
| 6-Chloronicotinic acid Preparation Products And Raw materials |
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