| N-desalkylflurazepam Basic information |
| Product Name: | N-desalkylflurazepam |
| Synonyms: | NORFLUDIAZEPAM;Dealkylflurazepam;Descarbethoxyloflazepate;Flurazepam M (des-alkyl);Flurazepam M (N-1-des-alkyl);Flurazepam, des-alkyl;N-1-desalkyl-flurazepam;N-Desalkyl-2-oxoquazepam |
| CAS: | 2886-65-9 |
| MF: | C15H10ClFN2O |
| MW: | 288.7 |
| EINECS: | 220-748-3 |
| Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;pharmacetical;(intermediate of fludiazepam,flurazepam);Aromatics;Heterocycles;medical intermediate |
| Mol File: | 2886-65-9.mol |
| N-desalkylflurazepam Chemical Properties |
| Melting point | 204-206°C |
| Boiling point | 454.0±45.0 °C(Predicted) |
| density | 1.39±0.1 g/cm3(Predicted) |
| Fp | 9℃ |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 11.55±0.70(Predicted) |
| CAS DataBase Reference | 2886-65-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Norfludiazepam(2886-65-9) |
| Safety Information |
| Hazard Codes | F,T |
| Risk Statements | 11-23/24/25-39/23/24/25 |
| Safety Statements | 22-24/25-45-36/37-16-7 |
| RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 2 |
| RTECS | DF2370100 |
| HS Code | 2933997500 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| N-desalkylflurazepam Usage And Synthesis |
| Description | Desalkylflurazepam (Item No. 18484) is an analytical reference material that is structurally categorized as a benzodiazepine. It is an active metabolite of several benzodiazepines, including flurazepam , flutoprazepam, fludiazepam, midazolam, and quazepam. Desalkylflurazepam inhibits L-type voltage-gated calcium channels (Cav; IC50s = 55 and 37 μM for Cav1.2 and 1.3, respectively) by positively modulating GABAA receptors. It can be detected in urine, serum, and meconium by LC-MS/MS. This product is intended for research and forensic applications. |
| Chemical Properties | Light Yellow Solid |
| Uses | The major human metabolite of flurazepam. This is a controlled drug precursor therefore a liscence may be required for purchase |
| Mode of action | N-Desalkylflurazepam is a benzodiazepine analog and an active metabolite of several other benzodiazepine drugs including flurazepam, flutoprazepam, fludiazepam, midazolam, flutazolam, quazepam, and ethyl loflazepate. It is long-acting, prone to accumulation, and binds unselectively to the various benzodiazepine receptor subtypes. It has been sold as a designer drug from 2016 onward. |
| N-desalkylflurazepam Preparation Products And Raw materials |
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