| Fmoc-Trp(Boc)-OH Basic information |
| Product Name: | Fmoc-Trp(Boc)-OH |
| Synonyms: | FMOC-TRP(BOC)-OH;FMOC-TRP(BOC);FMOC-TRYPTOPHAN(BOC)-OH;FMOC-NIN-T-BUTYLOXYCARBONYL-L-TRYPTOPHAN;FMOC-N-IN-BOC-L-TRYPTOPHAN;FMOC-N-BOC-L-TRYPTOPHAN;FMOC-L-TRP(BOC);FMOC-L-TRP(BOC)-OH |
| CAS: | 143824-78-6 |
| MF: | C31H30N2O6 |
| MW: | 526.58 |
| EINECS: | 604-383-0 |
| Product Categories: | Tryptophan [Trp, W];Fmoc-Amino Acids and Derivatives;Amino Acids;Amino Acids (N-Protected);Biochemistry;Fmoc-Amino Acids;Fmoc-Amino acid series |
| Mol File: | 143824-78-6.mol |
| Fmoc-Trp(Boc)-OH Chemical Properties |
| Melting point | ca 97℃ |
| alpha | -21 º (c=1%, DMF) |
| density | 1.28±0.1 g/cm3(Predicted) |
| refractive index | -20 ° (C=1, DMF) |
| storage temp. | 2-8°C |
| pka | 3.71±0.10(Predicted) |
| form | Solid |
| color | White to Orange to Green |
| optical activity | [α]20/D 21±2°, c = 1% in DMF |
| Sensitive | Moisture Sensitive |
| BRN | 7698009 |
| InChIKey | ADOHASQZJSJZBT-SANMLTNESA-N |
| CAS DataBase Reference | 143824-78-6(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi,N |
| Risk Statements | 36/37/38-51/53-43 |
| Safety Statements | 22-24/25-36/37/39-27-26-61-37-24 |
| RIDADR | 3077 |
| WGK Germany | 3 |
| F | 10-21 |
| HazardClass | 9 |
| HS Code | 29339900 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| Fmoc-Trp(Boc)-OH Usage And Synthesis |
| Chemical Properties | White solid |
| Uses | Fmoc-Trp(Boc)-OH is a very useful synthetic intermediate. It is used to prepare Trp containing-peptides. |
| Uses | Fmoc-Trp(Boc)-OH can be used for the synthesis of analogs of glucagon-like peptide-1 (GLP-1) for the treatment of type 2 diabetes and various peptides by Fmoc solid phase peptide synthesis (SPPS). |
| General Description | The use of this N-in-Boc protected derivative overcomes most of the problems associated with the preparation of Trp containing-peptides by Fmoc SPPS [1]. Cleavage with TFA generates an N-in-carboxy indole which protects the Trp from alkylation [1, 2, 3] and sulfonation [1, 4, 5, 6, 7]. The N-in-carboxy group is removed under aqueous conditions during normal work-up of the peptide.The product number for this product was previously 04-12-1103.To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”. |
| Fmoc-Trp(Boc)-OH Preparation Products And Raw materials |
| Preparation Products | L-Phe-D-Trp-OH-->Fmoc-β-HomoTrp(Boc)-OH |
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