| Diethyl ethoxymethylenemalonate Basic information |
| Product Name: | Diethyl ethoxymethylenemalonate |
| Synonyms: | 1,1-DICARBETHOXY-2-ETHOXYETHYLENE;2,2-DICARBETHOXYVINYL ETHYL ETHER;AKOS BBS-00004230;LABOTEST-BB LT02094814;ETHYL A-CARBETHOXY-B-ETHOXYACRYLATE;ETHYL ETHOXYMETHYLENE MALONATE;ETHYL 3-ETHOXY-2-(ETHOXYCARBONYL)ACRYLATE;EMME |
| CAS: | 87-13-8 |
| MF: | C10H16O5 |
| MW: | 216.23 |
| EINECS: | 201-725-7 |
| Product Categories: | Pharmaceuticals;C10 to C11;Pharmaceutical Intermediates;Carbonyl Compounds;Esters;Intermediates & Fine Chemicals |
| Mol File: | 87-13-8.mol |
| Diethyl ethoxymethylenemalonate Chemical Properties |
| Melting point | -33°C |
| Boiling point | 279-283 °C(lit.) |
| density | 1.080 g/mL at 20 °C(lit.) |
| vapor pressure | <0.1 hPa |
| refractive index | n |
| Fp | 311 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear colorless to light yellow |
| Water Solubility | insoluble |
| BRN | 880058 |
| InChIKey | LTMHNWPUDSTBKD-UHFFFAOYSA-N |
| LogP | 1.5-2.1 at pH7 |
| CAS DataBase Reference | 87-13-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Propanedioic acid, (ethoxymethylene)-, diethyl ester(87-13-8) |
| EPA Substance Registry System | Propanedioic acid, (ethoxymethylene)-, diethyl ester (87-13-8) |
| Safety Information |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38-42/43 |
| Safety Statements | 26-36/37/39-27-24/25 |
| WGK Germany | 1 |
| RTECS | OO1100000 |
| Autoignition Temperature | 215 °C |
| TSCA | Yes |
| HS Code | 29189090 |
| Toxicity | LD50 orally in Rabbit: 925 mg/kg LD50 dermal Rat > 2000 mg/kg |
| MSDS Information |
| Provider | Language |
|---|---|
| Diethyl ethoxymethylenemalonate | English |
| SigmaAldrich | English |
| ACROS | English |
| ALFA | English |
| Diethyl ethoxymethylenemalonate Usage And Synthesis |
| Chemical Properties | CLEAR COLOURLESS TO LIGHT YELLOW LIQUID |
| Uses | Intermediate in the production of Flumequine |
| Uses | Diethyl ethoxymethylenemalonate is used for synthesis of pyrido[3,2-e]pyrimido[1,2-c]pyrimidines. Initially, it was used to monitor lysine decarboxylase activity. It is useful in the determination of amino acids by precolumn derivatization by using reversed-phase high-performance liquid chromatography (HPLC). It plays an important role in the Gould-Jacobs reaction to prepare quinolines. For example, anile reacts with this reagent to give 4-hydroxyquinoline. It acts as an intermediate in the production of flumequine, which is a fluoroquinolone antibiotic. |
| Safety Profile | Moderately toxic by ingestion. A skin irritant. A combustible liquid. When heated to decomposition it emits acrid smoke and irritating fumes. |
| Purification Methods | Likely impurity is diethyl diethoxymethylene malonate which is difficult to separate from diethyl ethoxymethylene malonate by distillation, and it is necessary to follow the course of the distillation by the change in refractive index instead of boiling point. After a low boiling fraction is collected, there is obtained an intermediate fraction (n 20 1.414—1.458), the size of which depends on the amount of the diethoxymethylene compound. This fraction is fractionated through a 5inch Vigreux column (p 11) at low pressure avoiding interruption in heating. Fraction b 108-110o/0.25mm is ca 10o lower than the submitters' fraction (b 97.2o/0.25mm, n D 1.4612—1.4623) [Org Synth Coll Vol III 395 1955, Fuson et al. J Org Chem 11 197 1946, Duff & Kendal J Chem Soc 893 1948]. [Beilstein 3 IV 1192.] |
| Diethyl ethoxymethylenemalonate Preparation Products And Raw materials |
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