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| Ammothamnine Basic information |
| Product Name: | Ammothamnine | | Synonyms: | OXYMATRINE;1-oxide,(1-beta)-matridin-15-on;1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, dodecahydro-, 4-oxide, (4R,7aS,13aR,13bR,13cS)-;Ammothamnine
Oxymatrine;Oxymatrine, 98%, from Sophora flavescens Aiton;(4R,7aS,13aR,13bR,13cS)-dodecahydro-4-oxide-1H,5H,10H-dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one;Oxymatrine 16837-52-8;matrine,1-oxide | | CAS: | 16837-52-8 | | MF: | C15H24N2O2 | | MW: | 264.36 | | EINECS: | 605-514-4 | | Product Categories: | Pyrazoles;Inhibitors;Plant extracts;chemical reagent;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Pharmaceutical material and intermeidates;Alkaloids;Natural Plant Extract;Plant extract;pharmaceutical intermediate;phytochemical | | Mol File: | 16837-52-8.mol |
| Ammothamnine Chemical Properties |
| Melting point | 208℃ | | storage temp. | Inert atmosphere,2-8°C | | solubility | methanol: soluble10mg/mL, clear, colorless | | pka | 4.87±0.20(Predicted) | | form | powder | | color | white to off-white | | Stability: | Hygroscopic | | InChIKey | XVPBINOPNYFXID-LHDUFFHYSA-N |
| Ammothamnine Usage And Synthesis |
| Description | An alkaloid from Sophora angustifolia var. flavescens S. and Z., the bas'e crystal_x0002_lizes as the monohydrate having the lower melting point given above. It is
dextrorotatory with [α]19D + 47.7° (EtOH) and yields crystalline salts and
derivatives: hydrobromide, m.p. 21SoC; aurichloride, m.p. 207°C (dec.); perchlorate, m.p. 240°C (dec.); picrate, m.p. 21SoC and the methochloride aurichloride, m.p. 18SoC (dec.). Ochiai and Ito have shown that it is formed by the
action of hydrogen peroxide on Matrine (q.v.), indicating that its structure is
matrine-N-oxide. | | Description | Oxymatrine is a natural alkaloid isolated from the root of S. flavescens, an herb used in traditional Chinese herbal medicine. It has antiviral properties, inhibiting the replication of hepatitis B alone and in combination with lamivudine. Oxymatrine also prevents fibrosis in a number of organs including liver, at least in part by interfering with TGF-β signaling. This compound also induces apoptosis in certain cancer cells and ameliorates inflammation by impairing the translocation of nuclear factors-κB. | | Uses | Oxymatrine is a an anti-tumor agent triggering apoptosis in human leukemia cells. | | Uses | antifungal, hepatoprotectant | | References | Kondo et al., Arch. Pharm., 275,493 (1937)
Ochiai, Ito., Ber., 81,938 (1938) |
| Ammothamnine Preparation Products And Raw materials |
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