Other grades of this product :
| koumine Basic information |
| Product Name: | koumine | | Synonyms: | koumine;(3R,7alpha,20alpha)-1,2,18,19-Tetradehydro-3,17-epoxy-7,20(2H,19H)cyclovobasan;7,20(2H,19H)-Cyclovobasan, 1,2,18,19-tetradehydro-3,17-epoxy-, (3R,7alpha,20alpha)-;6,4-(Epoxymethano)-3,11b-methano-11bH-pyrido[4,3-c]carbazole, 11c-ethenyl-1,2,3,4,4a,5,6,11c-octahydro-2-methyl-, (3S,4S,4aR,6R,11bS,11cS)-;(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole | | CAS: | 1358-76-5 | | MF: | C20H22N2O | | MW: | 306.4 | | EINECS: | | Product Categories: | Alkaloids;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 1358-76-5.mol |
| koumine Chemical Properties |
| Melting point | 168℃ | | Boiling point | 436.5±45.0 °C(Predicted) | | density | 1.42 | | storage temp. | 2-8°C | | pka | 8.67±0.40(Predicted) |
| koumine Usage And Synthesis |
| Description | The Chinese drug 'Kou-wen', said to be derived from Gelsemium elegans Benth.,
is stated to contain this alkaloid which forms rhombic prisms from Me2 CO. It
has [α]23D - 265° (EtOH) and forms a crystalline hydrochloride, m.p. 255°C
(dec.) and a hydrobromide, m.p. 269°C (dec.). | | Occurrence | Koumine is an alkaloid isolated from Gelsemium elegans Benth. | | Uses | Koumine is known to attenuate the lipopolysaccharide-stimulated inflammation in RAW264.7 macrophages. | | References | Chou, Pak, Hou., Chin. 1. Physiol., 5, 345 (1931)
Chou, Wang, Chen., ibid, 8,40 (1934)
Chi, Kao, Huang., 1. Amer. Chem. Soc., 60, 1723 (1938) |
| koumine Preparation Products And Raw materials |
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