Other grades of this product :
| 2-Biphenylcarboxylic acid Basic information |
| 2-Biphenylcarboxylic acid Chemical Properties |
| Melting point | 111-113 °C(lit.) | | Boiling point | 199 °C10 mm Hg(lit.) | | density | 1.1184 (rough estimate) | | refractive index | 1.5954 (estimate) | | Fp | 343-344°C | | storage temp. | Sealed in dry,Room Temperature | | form | Crystalline Powder | | pka | 3.46(at 25℃) | | color | White to beige | | Water Solubility | insoluble | | BRN | 974075 | | InChIKey | ILYSAKHOYBPSPC-UHFFFAOYSA-N | | CAS DataBase Reference | 947-84-2(CAS DataBase Reference) | | NIST Chemistry Reference | 2-Biphenylcarboxylic acid(947-84-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39-37 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29163900 |
| 2-Biphenylcarboxylic acid Usage And Synthesis |
| Chemical Properties | 2-Biphenylcarboxylic acid is White powder
| | Uses | 2-Biphenylcarboxylic acid is used in the preparation of neuropeptide FF receptor antagonists. In addition it is used in the synthesis of disubstituted piperidines as orexin receptor antagonists.
| | Uses | It is used as a pharmaceutical intermediate. he reaction of 2?-substituted biphenyl-2-carboxylic acids (where the 2?-substituent is H, CO2H, NO2, Cl, OMe, or CO2Me) with lead tetra-acetate in refluxing benzene solution, under a nitrogen atmosphere, affords 3,4-benzocoumarin as a major organic product. | | Synthesis Reference(s) | The Journal of Organic Chemistry, 43, p. 447, 1978 DOI: 10.1021/jo00397a015 | | Purification Methods | Crystallise the acid from *C6H6/pet ether or aqueous EtOH. [Beilstein 9 IV 2472.] |
| 2-Biphenylcarboxylic acid Preparation Products And Raw materials |
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