| 2-Biphenylcarboxylic acid Basic information |
| Product Name: | 2-Biphenylcarboxylic acid |
| Synonyms: | O-PHENYLBENZOIC ACID;TIMTEC-BB SBB007790;RARECHEM AL BE 0859;[1,1’-Biphenyl]-2-carboxylicacid;LABOTEST-BB LT0;2-Biphenylcarboxylic acid2;-Methoxyphenyl)proanol-methyl-d3;-Aminobenzyl)thio]cellobiose |
| CAS: | 947-84-2 |
| MF: | C13H10O2 |
| MW: | 198.22 |
| EINECS: | 213-432-1 |
| Product Categories: | Biphenyl series;Biphenyl derivatives;Benzene derivatives;Organic acids |
| Mol File: | 947-84-2.mol |
| 2-Biphenylcarboxylic acid Chemical Properties |
| Melting point | 111-113 °C(lit.) |
| Boiling point | 199 °C10 mm Hg(lit.) |
| density | 1.1184 (rough estimate) |
| refractive index | 1.5954 (estimate) |
| Fp | 343-344°C |
| storage temp. | Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 3.46(at 25℃) |
| color | White to beige |
| Water Solubility | insoluble |
| BRN | 974075 |
| InChIKey | ILYSAKHOYBPSPC-UHFFFAOYSA-N |
| CAS DataBase Reference | 947-84-2(CAS DataBase Reference) |
| NIST Chemistry Reference | 2-Biphenylcarboxylic acid(947-84-2) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36-37/39-37 |
| WGK Germany | 3 |
| HazardClass | IRRITANT |
| HS Code | 29163900 |
| MSDS Information |
| Provider | Language |
|---|---|
| 2-Phenylbenzoic acid | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| 2-Biphenylcarboxylic acid Usage And Synthesis |
| Chemical Properties | 2-Biphenylcarboxylic acid is White powder |
| Uses | 2-Biphenylcarboxylic acid is used in the preparation of neuropeptide FF receptor antagonists. In addition it is used in the synthesis of disubstituted piperidines as orexin receptor antagonists. |
| Uses | It is used as a pharmaceutical intermediate. he reaction of 2?-substituted biphenyl-2-carboxylic acids (where the 2?-substituent is H, CO2H, NO2, Cl, OMe, or CO2Me) with lead tetra-acetate in refluxing benzene solution, under a nitrogen atmosphere, affords 3,4-benzocoumarin as a major organic product. |
| Synthesis Reference(s) | The Journal of Organic Chemistry, 43, p. 447, 1978 DOI: 10.1021/jo00397a015 |
| Purification Methods | Crystallise the acid from *C6H6/pet ether or aqueous EtOH. [Beilstein 9 IV 2472.] |
| 2-Biphenylcarboxylic acid Preparation Products And Raw materials |
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