| 6-HYDROXYDOPAMINE HYDROBROMIDE Basic information |
| Product Name: | 6-HYDROXYDOPAMINE HYDROBROMIDE |
| Synonyms: | 1,2,4-Benzenetriol,5-(2-aminoethyl)-, hydrobromide (1:1);2,4-benzenetriol,5-(2-aminoethyl)-hydrobromide;2-(2,4,5-TRIHYDROXYPHENYL)ETHYLAMINE HYDROBROMIDE;2,5-DIHYDROXYTYRAMINE HYDROBROMIDE;2,4,5-TRIHYDROXYPHENETHYLAMINE HYDROBROMIDE;6-HYDROXYDOPAMINE HBR;6-HYDROXYDOPAMINE HYDROBROMIDE;2,4,5-Trihydroxyphenethylamine |
| CAS: | 636-00-0 |
| MF: | C8H12BrNO3 |
| MW: | 250.09 |
| EINECS: | 211-247-0 |
| Product Categories: | Dopamine receptor;Amino Alcohols;Bioactive Small Molecules;Building Blocks;Cell Biology;Chemical Synthesis;H;Organic Building Blocks;Oxygen Compounds |
| Mol File: | 636-00-0.mol |
| 6-HYDROXYDOPAMINE HYDROBROMIDE Chemical Properties |
| Melting point | 216-220 °C(lit.) |
| storage temp. | -20°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water (Slightly) |
| form | solid |
| color | tan to brown |
| BRN | 3713280 |
| Stability: | Hygroscopic, Light Sensitive |
| InChIKey | MLACDGUOKDOLGC-UHFFFAOYSA-N |
| CAS DataBase Reference | 636-00-0(CAS DataBase Reference) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | DC4600000 |
| F | 3-10 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ACROS | English |
| 6-HYDROXYDOPAMINE HYDROBROMIDE Usage And Synthesis |
| Description | 6-OHDA is a catecholaminergic neurotoxin that has been used to induce dopaminergic lesions and parkinsonian symptoms as a model of Parkinson''s disease in rodents. It induces locomotor impairment in mice and loss of tyrosine hydroxylase-reactive neurons in mouse brain when administered into the substantia nigra, medial forebrain bundle (MFB), or striatum at doses of 9, 6, and 18 μg, respectively. Intracisternal administration of 6-OHDA (200 μg) decreases dopamine and norepinephrine levels in rat brain. It induces apoptosis in primary rat cortical cells and PC12 rat adrenal cells when used at a concentration of 50 μM. 6-OHDA (75 μM) activates caspase-3, -8, and -9 in a time-dependent manner and increases the level of intracellular reactive oxygen species (ROS) in PC12 cells and induces apoptosis in rat substantia nigra when stereotaxically injected into the right MFB. |
| Chemical Properties | beige to brown crystalline powder |
| Uses | 6-Hydroxydopamine is a selective catecholaminergic neurotoxin. Studies show that 6-Hydroxydopamine can be used to create an animal model of Parkinson''s disease as it causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats. 6-Hydroxydopamine induces apoptosis in PC12 cells. |
| General Description | Solutions should be freshly prepared and protected from exposure to light. |
| Biochem/physiol Actions | Neurotoxin that destroys catecholaminergic terminals. |
| 6-HYDROXYDOPAMINE HYDROBROMIDE Preparation Products And Raw materials |
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