[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Six Chongqing Chemdad Co. ，Ltd

Product

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid

CAS No.：166108-71-0

Other grades of this product :

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Basic information

Product Name:	[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid
Synonyms:	Fmoc-8-amino-3,6-dioxaoctanoic acid, Fmoc-AEEA;Fmoc-PEG2-acetic acid;{2-[2-(Fmoc-amino)ethoxy]ethoxy}acetic acid≥ 99% (HPLC);Fmoc-NH-(PEG)-COOH (9 atoms) Novabiochem;1-(9H-Fluoren-9-yl)-3-oxo-2,7,1-trioxa-4-azadodecan-12-oic acid;9-FLUORENYLMETHOXYCARBONYL-8-AMINO-3,6-DIOXAOCTANOIC ACID;8-(FMOC-AMINO)-3,6-DIOXA-OCTANOIC ACID;8-FLUORENYLMETHOXYCARBONYLAMINO-3,6-DIOXAOCTANOIC ACID
CAS:	166108-71-0
MF:	C21H23NO6
MW:	385.41
EINECS:	200-111-8
Product Categories:	peg
Mol File:	166108-71-0.mol

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Chemical Properties

Melting point	90-92℃
Boiling point	631.4±45.0 °C(Predicted)
density	1.265±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	3.40±0.10(Predicted)
form	Crystalline Powder
color	White
InChIKey	XQPYRJIMPDBGRW-UHFFFAOYSA-N
CAS DataBase Reference	166108-71-0(CAS DataBase Reference)

Safety Information

Safety Statements	22-24/25
WGK Germany	3
HS Code	29189900

MSDS Information

Provider	Language
SigmaAldrich	English

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Usage And Synthesis

Uses	[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid is a hydrophilic, heterobifunctional spacer.
Description	Fmoc-NH-PEG2-CH2COOH is a PEG linker containing an Fmoc-protected amine and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties	White solid
Uses	Hydrophillic spacer group.
Uses	8-(Fmoc-amino)-3,6-dioxaoctanoic Acid is a hydrophilic, heterobifunctional spacer.

[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid Preparation Products And Raw materials

Raw materials

Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Sulfuric acid-->Dichloromethane-->N,N-Dimethylformamide-->Potassium carbonate-->Triethylamine-->Hydrazinium hydroxide solution-->Tosyl chloride-->Chromium(VI) oxide-->Phthalimide-->DBU-->Triethylene glycol-->9-Fluorenylmethyl chloroformate-->N-(9-Fluorenylmethoxycarbonyloxy)succinimide

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