| (R)-(-)-alpha-Methoxyphenylacetic acid Basic information |
| Product Name: | (R)-(-)-alpha-Methoxyphenylacetic acid |
| Synonyms: | (R)-(-)-METHOXYPHENYLACETIC ACID;O-METHYL-D-MANDELIC ACID;(R)-(-)-ALPHA-METHOXYPHENYLACETIC ACID;(R)-ALPHA-METHOXYPHENYLACETIC ACID;(R)-(-)-A-METHOXYPHENYLACETIC ACID;Benzeneacetic acid, alpha-methoxy-, (R)-;Acetic acid, methoxyphenyl- (8CI);Benzeneacetic acid, .a |
| CAS: | 3966-32-3 |
| MF: | C9H10O3 |
| MW: | 166.17 |
| EINECS: | 223-580-9 |
| Product Categories: | Analytical Chemistry;Carboxylic Acids (Chiral);Chiral Building Blocks;e.e. / Absolute Configuration Determination (NMR);Enantiomer Excess & Absolute Configuration Determination;Synthetic Organic Chemistry |
| Mol File: | 3966-32-3.mol |
| (R)-(-)-alpha-Methoxyphenylacetic acid Chemical Properties |
| Melting point | 66-68 °C(lit.) |
| alpha | -160.4 º (C=1, MEOH) |
| Boiling point | 164-166°C 18mm |
| density | 1.1708 (rough estimate) |
| refractive index | -147 ° (C=0.5, EtOH) |
| Fp | 164-166°C/18mm |
| storage temp. | 2-8°C |
| solubility | Chloroform, Ethanol, Methanol |
| pka | 3.10±0.10(Predicted) |
| form | Fine Crystalline Powder or Needles |
| color | White |
| optical activity | [α]20/D -150±3°, c = 0.5% in ethanol |
| BRN | 3589257 |
| CAS DataBase Reference | 3966-32-3(CAS DataBase Reference) |
| NIST Chemistry Reference | (R)-(-)-«alpha»-methoxyphenylacetic acid(3966-32-3) |
| Safety Information |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 29189900 |
| MSDS Information |
| Provider | Language |
|---|---|
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| (R)-(-)-alpha-Methoxyphenylacetic acid Usage And Synthesis |
| Chemical Properties | white fine crystalline powder or needles |
| Uses | (R)-(-)-α-Methoxyphenylacetic Acid is a useful synthetic intermediate. It is used as a reactant in the synthesis of dopamine receptor agonists. It can also be used to prepare hydroxytriamides as potent γ-secretase inhibitors. |
| General Description | (R)-(?)-α-Methoxyphenylacetic acid is a chiral derivatizating agent, which is employed for derivatizing enantiomers into diastereoisomers. |
| Purification Methods | Purify the acids by recrystallising from *C6H6/pet ether (b 80-100o). [Neilson & Peters J Chem Soc 1519 1962, Weizmann et al. J Am Chem Soc 70 1153 1948, Pirie & Smith J Chem Soc 338 1932, NMR: Dale & Mosher J Am Chem Soc 9 5 512 1973, for resolution: Roy & Deslongchamps Can J Chem 63 651 1985, Trost et al. J Am Chem Soc 1 0 8 4974 1986.] The racemic mixture has m 72o, b 121-122o/0.4mm, 165o/18mm (from pet ether) [Braun et al. Chem Ber 6 3 2847 1930]. [Beilstein 10 IV 566.] |
| (R)-(-)-alpha-Methoxyphenylacetic acid Preparation Products And Raw materials |
| Raw materials | DL-alpha-Methoxyphenylacetic acid |
Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.
日本语
한국어
Français
Deutsch
España
Türkiye