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| Bromo-PEG2-acid Basic information |
| Product Name: | Bromo-PEG2-acid | | Synonyms: | Br-PEG2-acid;Bromo-PEG2-propionic acid;Bromo-PEG2-acid;Bromo-PEG3-acid;3-(2-(2-Bromoethoxy)ethoxy)propanoic acid;CAS_1807503-92-9;Br-PEG2-CH2CH2COOH;Bromo-PEG2-C2-acid | | CAS: | 1807503-92-9 | | MF: | C7H13BrO4 | | MW: | 241.08 | | EINECS: | | Product Categories: | | Mol File: | 1807503-92-9.mol |
| Bromo-PEG2-acid Chemical Properties |
| Boiling point | 347.2±27.0 °C(Predicted) | | density | 1.464±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | pka | 4.27±0.10(Predicted) |
| Bromo-PEG2-acid Usage And Synthesis |
| Description | Bromo-PEG2-acid is a PEG linker containing a bromide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | | Uses | Bromo-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a bromo group at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. Bromo-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
| Bromo-PEG2-acid Preparation Products And Raw materials |
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