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| Diethyl cyanomethylphosphonate Basic information |
| Diethyl cyanomethylphosphonate Chemical Properties |
| Boiling point | 101-102 °C0.4 mm Hg(lit.) | | density | 1.095 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.434(lit.) | | Fp | >230 °F | | storage temp. | Inert atmosphere,2-8°C | | solubility | Chloroform (Soluble), Methanol (Slightly) | | form | Liquid | | color | Clear colorless to light yellow | | Specific Gravity | 1.1261.095 | | Water Solubility | Miscible with water, chloroform, terahydrofuran, ethyl acetate and methylene chloride. | | BRN | 1772981 | | InChIKey | KWMBADTWRIGGGG-UHFFFAOYSA-N | | CAS DataBase Reference | 2537-48-6(CAS DataBase Reference) | | NIST Chemistry Reference | Diethyl cyanomethylphosphonate(2537-48-6) |
| Diethyl cyanomethylphosphonate Usage And Synthesis |
| Chemical Properties | clear colorless to light yellow liquid | | Uses | Wittig reagent. | | Uses | Diethyl cyanomethyl phosphonate is used as an intermediate in Horner-Emmons reaction for the synthesis of substituted nitriles and their amide and heterocyclic derivatives. It is known as a modified Wittig reagent used in the preparation of alpha, beta-unsaturated nitriles from ketones or aldehydes like 3-hydroxy-3-methylbutanal. It reacts with epoxides and nitrones to prepare cyano-substituted cyclopropanes and aziridines respectively. It is actively involved in the synthesis of alpha-arylated alkanenitriles via reaction with aryl iodides in presence of CuI. | | General Description | Diethyl cyanomethylphosphonate is a useful chemical and medical intermediate, which can be used as raw material to synthesize nitrogen-haloamine precursor AEP-ADCT containing triazine-phosphate group |
| Diethyl cyanomethylphosphonate Preparation Products And Raw materials |
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